Evidence map›Paper›PMID 38438560›Full record

ArticlePediatric nephrology (Berlin, Germany)2024

Deriving and validating a protocol to determine the need for prophylactic peritoneal dialysis in neonates after cardiopulmonary bypass surgery.

Tennille N Webb, Santiago Borasino, Kristal M Hock, Inmaculada Aban, Daryl Ingram, Kara Short, Robert Dabal, David Askenazi

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tennille N WebbPediatrics/Pediatric Nephrology, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, USA. tennillewebb@uabmc.edu.ORCID 0000-0002-5506-2992
Santiago BorasinoPediatrics/Pediatric Cardiac Intensive Care Unit, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, USA.
Kristal M HockPediatrics/Pediatric Cardiac Intensive Care Unit, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, USA.
Inmaculada AbanSchool of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Daryl IngramPediatrics/Pediatric Nephrology, Children's of Alabama, Birmingham, AL, USA.
Kara ShortPediatrics/Pediatric Nephrology, Children's of Alabama, Birmingham, AL, USA.
Robert DabalPediatrics/Pediatric Cardiothoracic Surgery, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, USA.
David AskenaziPediatrics/Pediatric Nephrology, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, USA.
Children's of Alabama · USUniversity of Alabama at Birmingham · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Foundation for the National Institutes of Health P30DK079337NIDDK NIH HHS P30 DK079337
6 · The paper itself

Abstract

backgroundProphylactic peritoneal dialysis (PD) in neonates undergoing cardiopulmonary bypass (CPB) is safe and improves outcomes. We sought to (1) derive the pre-operative characteristics of neonates who are most likely to benefit from PD after CPB and (2) validate a new prophylactic PD protocol based on our retrospective analysis.

methodsFirst, we retrospectively evaluated neonates requiring cardiac surgery with CPB from October 2012 to June 2016. We categorized neonates as those who "needed PD" and those who "did not need PD" based on prior experience with neonates requiring kidney support therapy. Pre-operative serum creatinine ≥ 0.8 mg/dL, pre-operative weight ≤ 2.5 kg, or having an open chest post-operatively were independently associated with "needed PD." Next, beginning in March 2019, we implemented a new prophylactic PD protocol in which only those who met at least one of the three criteria derived in the retrospective analysis had a PD catheter placed in the OR.

resultsIn Era 2, after the implementation of a new prophylactic PD protocol, 100% of neonates in the "needed PD" group had a PD catheter placed in the OR, which was more than in the prior era (Era 1 = 86.6%) (p = 0.05). Only 26.1% in the "did not need PD" group had a PD catheter placed in the OR which was less than in the prior era (Era 1 = 50.6%) (p < 0.01).

conclusionsWe successfully developed and implemented an evidence-based prophylactic PD protocol that has improved our ability to provide prophylactic PD in neonates after CPB.

Indexed as

Cardiopulmonary BypassPeritoneal DialysisAcute Kidney InjuryClinical ProtocolsCreatinineFemaleHumansInfant, NewbornMalePostoperative ComplicationsRetrospective StudiesCreatinineAcute kidney injuryCardiopulmonary bypassNeonatesPeritoneal dialysis

Identifiers

PMID38438560
PMCPMC11147869
OpenAlexW4392383447

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.