ArticlePediatric research2024
Effects of hemodynamic alterations and oxygen saturation on cerebral perfusion in congenital heart disease.
Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Brain injury in congenital heart disease: pathophysiology, MRI patterns, and perioperative risk factors.Pediatric research · 2026Review
- Academic Achievements in Adolescents With Congenital Heart Disease: A Total Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Risk factors for 30-day mortality following major neonatal surgery: insights from a 10-year cohort in southern Tunisia.Surgery today · 2026Article
- Cerebral hemodynamics in early adolescents with congenital heart disease after infant open-heart surgery.Pediatric research · 2026Article
- High Burden of Neurodevelopmental Delays in Children Undergoing Heart Transplantation in Early Childhood.Pediatric cardiology · 2026Article
- Ventricular cardiac magnetic resonance traits and schizophrenia risk: a UK Biobank and Mendelian randomization study.Frontiers in psychiatry · 2026Article
- Adults With Congenital Heart Disease Have an Increased Prevalence of Autoimmunity.JACC. Advances · 2025Article
- PINNing cerebral blood flow: analysis of perfusion MRI in infants using physics-informed neural networks.Frontiers in network physiology · 2025Article
- Association of preoperative cerebral oxygenation with concurrent neurobehavioral scores in term neonates with congenital heart disease compared to healthy controls.Frontiers in pediatrics · 2025Article
- MRI measurement of cerebral perfusion in severe congenital heart disease: just the first step.Pediatric research · 2024Article
- Quantitative Magnetic Resonance Cerebral Spinal Fluid Flow Properties and Executive Function Cognitive Outcomes in Congenital Heart Disease.medRxiv : the preprint server for health sciences · 2024Article
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11 authors at 3 institutions in 1 country.
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Abstract
backgroundPatients with severe congenital heart disease (CHD) are at risk for neurodevelopmental impairment. An abnormal cerebral blood supply caused by the altered cardiac physiology may limit optimal brain development. The aim of this study was to evaluate the effect of a systemic-to-pulmonary shunt, aortic arch obstruction and arterial oxygen saturation on cerebral perfusion in patients with severe CHD.
methodsPatients with severe CHD requiring cardiac surgery within the first six weeks of life, who underwent pre- and/or postoperative brain magnetic resonance imaging (MRI), and healthy controls with one postnatal scan were included. Cerebral perfusion in deep and cortical gray matter was assessed by pseudocontinuous arterial spin labeling MRI.
resultsWe included 59 CHD and 23 healthy control scans. The presence of a systemic-to-pulmonary shunt was associated with decreased perfusion in cortical (p = 0.003), but not in deep gray matter (p = 0.031). No evidence for an effect of aortic arch obstruction and arterial oxygen saturation on cerebral perfusion was found. After adjusting for hemodynamic and oxygen saturation parameters, deep (p = 0.018) and cortical (p = 0.012) gray matter perfusion was increased in patients with CHD compared to controls.
conclusionWe detected regional differences in compensation to the cerebral steal effect in patients with severe CHD. IMPACT: Patients with severe congenital heart disease (CHD) have altered postnatal brain hemodynamics. A systemic-to-pulmonary shunt was associated with decreased perfusion in cortical gray matter but preserved perfusion in deep gray matter, pointing towards regional differences in compensation to the cerebral steal effect. No effects of aortic arch obstruction and arterial oxygenation on cerebral perfusion were seen. Cerebral perfusion was increased in patients with CHD compared to healthy controls after adjusting for hemodynamic alterations and oxygen saturation. To improve neuroprotection and neurodevelopmental outcomes, it is important to increase our understanding of the factors influencing cerebral perfusion in neonates with severe CHD.
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