Evidence map›Paper›PMID 38438404›Full record

ArticleScientific reports2024

The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds.

Seth A Schobel, Eric R Gann, Desiree Unselt, Scott F Grey, Felipe A Lisboa, Meenu M Upadhyay, Michael Rouse, Simon Tallowin, Nicholas A Be, Xijun Zhang and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. High-qualityMicrobiology spectrum · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Seth A Schobel *Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. seth.schobel-mchugh.ctr@usuhs.edu.
Eric R Gann *Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Desiree Unselt *Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Scott F GreyDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Felipe A LisboaDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Meenu M UpadhyayUniformed Services University (USU) Surgical Critical Care Initiative (SC2i), Bethesda, MD, USA.
Michael RouseDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Simon TallowinDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Nicholas A BePhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Xijun ZhangUniformed Services University (USU) The American Genome Center (TAGC), Bethesda, MD, USA.
Clifton L DalgardUniformed Services University (USU) The American Genome Center (TAGC), Bethesda, MD, USA.
Matthew D WilkersonUniformed Services University (USU) The American Genome Center (TAGC), Bethesda, MD, USA.
Milos HauskrechtDepartment of Computer Science, University of Pittsburgh, Pittsburgh, PA, USA.
Stephen F BadylakDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Ruben ZamoraDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Yoram VodovotzDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Benjamin K PotterDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Thomas A DavisDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Eric A ElsterDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Uniformed Services University of the Health Sciences · USHenry M. Jackson Foundation · USUniversity of Pittsburgh · USLawrence Livermore National Laboratory · US

Funding

Defense Advanced Research Projects Agency D20AC00002Uniformed Services University of the Health Sciences HU0001-15-2-0001
6 · The paper itself

Abstract

A combination of improved body armor, medical transportation, and treatment has led to the increased survival of warfighters from combat extremity injuries predominantly caused by blasts in modern conflicts. Despite advances, a high rate of complications such as wound infections, wound failure, amputations, and a decreased quality of life exist. To study the molecular underpinnings of wound failure, wound tissue biopsies from combat extremity injuries had RNA extracted and sequenced. Wounds were classified by colonization (colonized vs. non-colonized) and outcome (healed vs. failed) status. Differences in gene expression were investigated between timepoints at a gene level, and longitudinally by multi-gene networks, inferred proportions of immune cells, and expression of healing-related functions. Differences between wound outcomes in colonized wounds were more apparent than in non-colonized wounds. Colonized/healed wounds appeared able to mount an adaptive immune response to infection and progress beyond the inflammatory stage of healing, while colonized/failed wounds did not. Although, both colonized and non-colonized failed wounds showed increasing inferred immune and inflammatory programs, non-colonized/failed wounds progressed beyond the inflammatory stage, suggesting different mechanisms of failure dependent on colonization status. Overall, these data reveal gene expression profile differences in healing wounds that may be utilized to improve clinical treatment paradigms.

Indexed as

Quality of LifeSurgical WoundAmputation, SurgicalExtremitiesGene Regulatory NetworksHumans

Identifiers

PMID38438404
PMCPMC10912443
OpenAlexW4392375253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.