Evidence map›Paper›PMID 38438248›Full record

ArticleLife science alliance2024

Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies.

Satadru K Lahiri, Feng Jin, Yue Zhou, Ann P Quick, Carlos F Kramm, Meng C Wang, Xander Ht Wehrens

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Junctophilin-2-orchestrated calcium signalosome regulates brown adipocyte thermogenesis and energy metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Cardiac Cell Remodeling in Obesity and Diabetes.Handbook of experimental pharmacology · 2026
    Review
  4. Nonstructural Roles of Junctophilin-2 in the Heart.JACC. Basic to translational science · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Satadru K LahiriCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9502-1530
Feng JinMolecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Yue ZhouHuffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
Ann P QuickCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-4223-6217
Carlos F KrammCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.
Meng C WangMolecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Xander Ht WehrensCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA wehrens@bcm.edu.ORCID 0000-0001-5044-672X
Baylor College of Medicine · USHoward Hughes Medical Institute · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5M
Noradrenergic mechanisms in breathing and respiratory pathophysiologiesR01HL130249 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI RAY, RUSSELL S · 2016 to 2024
$5.3M
METABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6M
Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapyRF1AG062257 · NIA · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN, WANG, MENG CARLA · 2018 to 2020
$4.0M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
Mechanisms underlying atrial fibrillation associated with chronic kidney diseaseR01HL147108 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA, WEHRENS, XANDER H.T. · 2019 to 2022
$2.0M
Vevo 3100 Ultrasound SystemS10OD032380 · OD · BAYLOR COLLEGE OF MEDICINE · PI WARD, CHRISTOPHER S · 2022 to 2022
$312k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA125123NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS R01 HL130249NHLBI NIH HHS R01 HL147108NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01 HL160992NIA NIH HHS RF1 AG062257NIDDK NIH HHS R01 DK114356NIH HHS S10 OD032380
6 · The paper itself

Abstract

Myocardial lipid metabolism is critical to normal heart function, whereas altered lipid regulation has been linked to cardiac diseases including cardiomyopathies. Genetic variants in the

Indexed as

CardiomyopathiesCardiomyopathy, DilatedHeart DiseasesAnimalsCeramidesHumansMembrane ProteinsMiceMuscle ProteinsMyocardiumCeramidesJP2 protein, mousejunctophilinMembrane ProteinsMuscle Proteins

Identifiers

PMID38438248
PMCPMC10912815
OpenAlexW4392429523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.