Evidence map›Paper›PMID 38438247›Full record

ArticleCancer science2024

Serum and tissue metallome of pancreatic ductal adenocarcinoma.

Sooin Byeon, Taymin du Toit-Thompson, Luke Hipperson, Sarah Maloney, Ross Wenzel, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal, Sumit Sahni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sooin ByeonFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Taymin du Toit-ThompsonFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Luke HippersonFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Sarah MaloneyFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Ross WenzelTrace Elements Laboratory, NSW Health Pathology, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
Anthony J GillFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Jaswinder S SamraFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Anubhav MittalFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Sumit SahniFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-2900-8845
The University of Sydney · AURoyal North Shore Hospital · AU

Funding

Philanthropic Funding
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) patients have late presentation at the time of diagnosis and a poor prognosis. Metal dyshomeostasis is known to play a role in cancer progression. However, the blood and tissue metallome of PDAC patients has not been assessed. This study aimed to determine the levels of essential and toxic metals in the serum and pancreatic tissue from PDAC patients. Serum samples were obtained from PDAC patients before surgical resection. Tissue (tumor and adjacent normal pancreas) were obtained from the surgically resected specimen. Inductively coupled plasma-mass spectrometry (ICP-MS) analysis was performed to quantify the levels of 10 essential and 3 toxic metals in these samples. Statistical analysis was performed to identify dysregulated metals in PDAC and their role as potential diagnostic and prognostic biomarkers. Significantly decreased serum levels of magnesium, potassium, calcium, iron, zinc, selenium, arsenic, and mercury and increased levels of molybdenum were shown to be associated with PDAC. There were significantly decreased levels of zinc, manganese and molybdenum, and increased levels of calcium and selenium in the pancreatic tumor tissue compared with the adjacent normal pancreas. Notably, lower serum levels of calcium, iron, and selenium, and higher levels of manganese, were significantly associated with a poor prognosis (i.e., overall survival) in PDAC patients. In conclusion, this is the first study to comprehensively assess the serum and tissue metallome of PDAC patients. It identified the association of metals with PDAC diagnosis and prognosis.

Indexed as

Biomarkers, TumorCarcinoma, Pancreatic DuctalPancreatic NeoplasmsAdultAgedCalciumFemaleHumansIronMagnesiumMaleMetalsMiddle AgedMolybdenumPancreasPrognosisBiomarkers, TumorCalciumIronMagnesiumMetalsMolybdenumSeleniumZincdiagnosisessential metalsinductively coupled plasma–mass spectrometrypancreatic ductal adenocarcinomaprognosistoxic metals

Identifiers

PMID38438247
PMCPMC11093192
OpenAlexW4392757527

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.