Evidence map›Paper›PMID 38438128›Full record

ArticleJournal of veterinary internal medicine

Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease.

Pak-Kan Tang, Rebecca F Geddes, Yu-Mei Chang, Rosanne E Jepson, Dirk Hendrik Nicolaas van den Broek, Nicola Lötter, Jonathan Elliott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Guideline
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Pak-Kan TangDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.ORCID https://orcid.org/0000-0002-8244-6131
Rebecca F GeddesDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.ORCID https://orcid.org/0000-0001-9216-4886
Yu-Mei ChangResearch Support Office, Royal Veterinary College, University of London, London, UK.
Rosanne E JepsonDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
Dirk Hendrik Nicolaas van den BroekDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-1231-7799
Nicola LötterDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
Jonathan ElliottDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
University of London · GBUniversity of Applied Sciences Utrecht · NL

Funding

Royal Canin
6 · The paper itself

Abstract

backgroundMicroscopic nephrocalcinosis is a common pathological feature of chronic kidney disease (CKD) in cats. Detection of macroscopic nephrocalcinosis using ultrasonography and its implications remain unexplored.

objectivesIdentify risk factors associated with ultrasound-diagnosed nephrocalcinosis and evaluate the influence of nephrocalcinosis on CKD progression. ANIMALS: Thirty-six euthyroid client-owned cats with CKD.

methodsProspective cohort study. Cats with CKD with and without ionized hypercalcemia were enrolled for renal ultrasonography. Cats were categorized according to the presence or absence of ultrasound-diagnosed nephrocalcinosis. Binary logistic regression was performed to identify nephrocalcinosis risk factors. The influence of nephrocalcinosis on CKD progression was assessed using linear mixed models.

resultsUltrasound-diagnosed nephrocalcinosis was evident in 61% of CKD cats overall, with increased prevalence (81%) in those with hypercalcemia. At enrollment, higher blood ionized calcium concentration (odds ratio [OR], 1.27 per 0.1 mg/dL; P = .01), plasma phosphate concentration (OR, 1.16 per 0.1 mg/dL; P = .05), plasma creatinine concentration (OR, 1.29 per 0.1 mg/dL; P = .02) and alanine aminotransferase activity (OR, 2.08 per 10 U/L; P = .04) were independent nephrocalcinosis risk factors. The rate of change in log-transformed fibroblast growth factor-23 differed significantly between groups (P = .04). Cats with CKD and nephrocalcinosis had increasing plasma creatinine concentrations (.03 ± .01 mg/dL/month; P = .04) and phosphate concentrations (.06 ± .02 mg/dL/month; P < .001) and decreasing body weight (.02 ± .01 kg/month; P < .001) over time. CONCLUSIONS AND CLINICAL IMPORTANCE: Nephrocalcinosis is prevalent in cats with CKD, especially in those with hypercalcemia. This pathological feature appears to be associated with CKD progression in cats.

Indexed as

Cat DiseasesNephrocalcinosisRenal Insufficiency, ChronicUltrasonographyAnimalsCalciumCatsCohort StudiesCreatinineFemaleHypercalcemiaMalePhosphatesProspective StudiesRisk FactorsCalciumCreatininePhosphatesCKD‐MBDfelinehypercalcemiamineralizationnephrolithiasisradiology and diagnostic imagingultrasonography

Identifiers

PMID38438128
PMCPMC11099775
OpenAlexW4392756786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.