Evidence map›Paper›PMID 38437666›Full record

ReviewNeuro-oncology2024

Integrating multi-modal imaging in radiation treatments for glioblastoma.

William G Breen, Madhava P Aryal, Yue Cao, Michelle M Kim

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Nano-Based Technology in Glioblastoma.Molecules (Basel, Switzerland) · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

William G BreenDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Madhava P AryalDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Yue CaoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Michelle M KimDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-7566-6411
University of Michigan · USMayo Clinic · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Dr. Kim R50 Research Specialist Clinician 2022R50CA276015 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michelle Miran Kim · 2023 to 2026
$687k
NCI NIH HHS P30 CA046592NCI NIH HHS R50 CA276015NIH HHS
6 · The paper itself

Abstract

Advances in diagnostic and treatment technology along with rapid developments in translational research may now allow the realization of precision radiotherapy. Integration of biologically informed multimodality imaging to address the spatial and temporal heterogeneity underlying treatment resistance in glioblastoma is now possible for patient care, with evidence of safety and potential benefit. Beyond their diagnostic utility, several candidate imaging biomarkers have emerged in recent early-phase clinical trials of biologically based radiotherapy, and their definitive assessment in multicenter prospective trials is already in development. In this review, the rationale for clinical implementation of candidate advanced magnetic resonance imaging and positron emission tomography imaging biomarkers to guide personalized radiotherapy, the current landscape, and future directions for integrating imaging biomarkers into radiotherapy for glioblastoma are summarized. Moving forward, response-adaptive radiotherapy using biologically informed imaging biomarkers to address emerging treatment resistance in rational combination with novel systemic therapies may ultimately permit improvements in glioblastoma outcomes and true individualization of patient care.

Indexed as

GlioblastomaRadiation OncologyBiomarkersHumansMulticenter Studies as TopicMultimodal ImagingProspective StudiesBiomarkersglioblastomaMRIPETradiomicsradiotherapy

Identifiers

PMID38437666
PMCPMC10911793
OpenAlexW4392384156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.