Evidence map›Paper›PMID 38437664›Full record

ReviewNeuro-oncology2024

The role of radiotherapy in immunotherapy strategies in the central nervous system.

Matthew Gallitto, Peter C Pan, Michael D Chan, Michael T Milano, Tony J C Wang

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Matthew GallittoDepartment of Radiation Oncology, Columbia University Irving Medical Center, New York, New York, USA.
Peter C PanDivision of Neuro-Oncology, Columbia University Irving Medical Center, New York, New York , USA.ORCID 0000-0001-8833-0757
Michael D ChanDepartment of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Michael T MilanoDepartment of Radiation Oncology, University of Rochester, Rochester, New York, USA.
Tony J C WangDepartment of Radiation Oncology, Columbia University Irving Medical Center, New York, New York, USA.
Columbia University Irving Medical Center · USUniversity of Rochester · USWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical efficacy and relative tolerability of adverse effects of immune checkpoint immunotherapy have led to its increasingly routine use in the management of multiple advanced solid malignancies. Radiation therapy (RT) is well-known to have both local and distant immunomodulatory effects, which has led to extensive investigation into the synergism of these 2 therapies. While the central nervous system (CNS) has historically been thought to be a sanctuary site, well-protected by the blood-brain barrier from the effects of immunotherapy, over the last several years studies have shown the benefits of these drugs, particularly in metastatic disease involving the CNS. This review explores current progress and the future of combination therapy with immune checkpoint inhibitors and RT.

Indexed as

Radiation OncologyBlood-Brain BarrierCentral Nervous SystemHumansImmunomodulationImmunotherapy

Identifiers

PMID38437664
PMCPMC10911795
OpenAlexW4392366967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.