Evidence map›Paper›PMID 38437549›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery.

Victoria Madigan, Yugang Zhang, Rumya Raghavan, Max E Wilkinson, Guilhem Faure, Elena Puccio, Michael Segel, Blake Lash, Rhiannon K Macrae, Feng Zhang

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Review
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  8. Review
  9. Capsid flexibility during Ty1 virus-like particle assembly.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Pseudouridine selects RNAs for extracellular transport.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
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  18. Article
  19. The myth of high-resolution liquid phase biological electron microscopy.Protein science : a publication of the Protein Society · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Victoria Madigan *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Yugang Zhang *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0002-1141-5821
Rumya Raghavan *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Max E WilkinsonBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0003-4738-9503
Guilhem FaureBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0001-9537-2277
Elena PuccioBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Michael SegelBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Blake LashBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Rhiannon K MacraeBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0002-7850-9056
Feng ZhangBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0002-7444-1103
Broad Institute · US

Funding

Engineering chimeric gene therapy vectors with enhanced packaging capacityF32AI161868 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MADIGAN, VICTORIA JANE · 2021 to 2023
$210k
Interrogation of retroelement-derived proteins for functional gene transferF31CA275339 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LASH, BLAKE · 2022 to 2024
$131k
NCI NIH HHS F31 CA275339NIAID NIH HHS F32 AI161868
6 · The paper itself

Abstract

A number of endogenous genes in the human genome encode retroviral

Indexed as

Antigens, NeoplasmCapsidNerve Tissue ProteinsAnimalsCryoelectron MicroscopyHumansMammalsRNA, MessengerAntigens, NeoplasmMa2 antigenNerve Tissue ProteinsRNA, Messengercapsidgene therapymRNA deliveryPNMAVLP

Identifiers

PMID38437549
PMCPMC10945824
OpenAlexW4392383103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.