Evidence map›Paper›PMID 38437540›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Taking a color photo: A homozygous 25-bp deletion in

Dengfeng Guan, Shuyan Sun, Lingyun Song, Pengpeng Zhao, Yonggang Nie, Xin Huang, Wenliang Zhou, Li Yan, Yinghu Lei, Yibo Hu and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Taking a color photo: A homozygous 25-bp deletion inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Dengfeng Guan *Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Shuyan Sun *Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Lingyun SongKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Pengpeng ZhaoShaanxi (Louguantai) Rescue and Breeding Center for Rare Wildlife, Xi'an 710402, China.
Yonggang NieKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-7554-979X
Xin HuangKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Wenliang ZhouCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.ORCID 0000-0002-1240-8842
Li YanKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Yinghu LeiShaanxi (Louguantai) Rescue and Breeding Center for Rare Wildlife, Xi'an 710402, China.
Yibo HuKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0003-3409-3164
Fuwen WeiKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-5233-1288
Chinese Academy of Sciences · CNSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou) · CN

Funding

CAS | BFSE | Key Research Program of Frontier Science, Chinese Academy of Sciences () XDB31000000CAS | Youth Innovation Promotion Association (YIPA) Y202026MOST | National Natural Science Foundation of China (NSFC) 31821001MOST | National Natural Science Foundation of China (NSFC) 32100329
6 · The paper itself

Abstract

Brown-and-white giant pandas (hereafter brown pandas) are distinct coat color mutants found exclusively in the Qinling Mountains, Shaanxi, China. However, its genetic mechanism has remained unclear since their discovery in 1985. Here, we identified the genetic basis for this coat color variation using a combination of field ecological data, population genomic data, and a CRISPR-Cas9 knockout mouse model. We de novo assembled a long-read-based giant panda genome and resequenced the genomes of 35 giant pandas, including two brown pandas and two family trios associated with a brown panda. We identified a homozygous 25-bp deletion in the first exon of

Indexed as

UrsidaeAmyloid beta-Protein PrecursorAnimalsAnimals, WildMiceMice, KnockoutPeptide HydrolasesAmyloid beta-Protein PrecursorPeptide HydrolasesBace2brown giant pandacoat color variationmelanosomepopulation genomics

Identifiers

PMID38437540
PMCPMC10945837
OpenAlexW4392367018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.