Evidence map›Paper›PMID 38436923›Full record

ArticleInternational journal of computer assisted radiology and surgery2024

OCT-based intra-cochlear imaging and 3D reconstruction: ex vivo validation of a robotic platform.

Maarten Schoovaerts, Mouloud Ourak, Gianni Borghesan, Tristan Putzeys, Emmanuel Vander Poorten, Nicolas Verhaert

Open access · greenAbstract readValidation Study
PubMed Publisher
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Intraoperative fusion of models and data for robust distance sensing.International journal of computer assisted radiology and surgery · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maarten SchoovaertsDepartment of Mechanical Engineering, KU Leuven, Celestijnenlaan 300, 3001, Leuven, Belgium. maarten.schoovaerts@kuleuven.be.ORCID http://orcid.org/0000-0001-7293-285X
Mouloud Ourak *Department of Mechanical Engineering, KU Leuven, Celestijnenlaan 300, 3001, Leuven, Belgium.
Gianni Borghesan *Department of Mechanical Engineering, KU Leuven, Celestijnenlaan 300, 3001, Leuven, Belgium.
Tristan PutzeysDepartment of Neurosciences, KU Leuven, Herestraat 49, 3001, Leuven, Belgium.
Emmanuel Vander PoortenDepartment of Mechanical Engineering, KU Leuven, Celestijnenlaan 300, 3001, Leuven, Belgium.
Nicolas VerhaertDepartment of Neurosciences, KU Leuven, Herestraat 49, 3001, Leuven, Belgium.
KU Leuven · BEFlanders Make (Belgium) · BE

Funding

Fonds Wetenschappelijk Onderzoek 1804816NFonds Wetenschappelijk Onderzoek 1SG1623NOnderzoeksraad, KU Leuven 3M210425
6 · The paper itself

Abstract

purposeThe small size of the cochlea, and its location deeply embedded in thick temporal bone, poses a challenge for intra-cochlear guidance and diagnostics. Current radiological imaging techniques are not able to visualize the cochlear microstructures in detail. Rotational optical coherence tomography (OCT) fibers show great potential for intra-cochlear guidance. The generated images could be used to map, and study, the tiny cochlear microstructures relevant for hearing.

methodsThis work describes the design of a rotational OCT probe with an outer diameter of 0.9 mm. It further discusses a robotic system, which features a remote center of motion mechanism, dedicated to the probe's positioning, fine manipulation and stable insertion into the cochlear micro-spaces. Furthermore, the necessary calibration steps for 3D reconstruction are described, followed by a detailed quantitative analysis, comparing the 3D reconstructions using a synthetic, 2:1 scaled scala tympani model with a reconstruction from micro-CT, serving as the ground truth. Finally, the potential of the system is demonstrated by scanning a single ex vivo cadaveric human cochlea.

resultsThe study investigates five insertions in the same 2:1 scaled tympani model, along with their corresponding 3D reconstruction. The comparison with micro-CT results in an average root-mean-square error of 74.2 µm, a signed distance error of 38.1 µm and a standard deviation of 63.6 µm. The average F-score of the reconstructions, using a distance threshold of 100 and 74.2 µm, resulted in 83.0% and 71.8%, respectively. Insertion in the cadaveric human cochlea showed the challenges for straight insertion, i.e., navigating the hook region.

conclusionOverall, the system shows great potential for intra-cochlear guidance and diagnostics, due to the system's capability for precise and stable insertion into the basal turn in the scala tympani. The system, combined with the calibration procedure, results in detailed and precise 3D reconstructions.

Indexed as

CochleaImaging, Three-DimensionalTomography, Optical CoherenceCadaverCochlear ImplantationHumansRobotic Surgical ProceduresX-Ray Microtomography3D reconstructionCochleaOptical coherence tomographyRobotic insertion

Identifiers

PMID38436923
OpenAlexW4392377082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.