Evidence map›Paper›PMID 38436761›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2024

Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.

Michele Sassano, Monireh Sadat Seyyedsalehi, Giulia Collatuzzo, Claudio Pelucchi, Rossella Bonzi, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Zuo-Feng Zhang, Lizbeth López-Carrillo and 25 more

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In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review.Indian journal of clinical biochemistry : IJCB · 2025
    Review
  4. Review
  5. Risk Factors and Prevention of Stomach Cancer, ExcludingThe Korean journal of helicobacter and upper gastrointestinal research · 2024
    Review
  6. Risk Prediction Models for Gastric Cancer: A Scoping Review.Journal of multidisciplinary healthcare · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 12 countries.

Michele SassanoDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Monireh Sadat SeyyedsalehiDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Giulia CollatuzzoDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Claudio PelucchiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Rossella BonziDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Monica FerraroniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
Guo-Pei YuMedical Informatics Center, Peking University, Beijing, China.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Lizbeth López-CarrilloMexico National Institute of Public Health, Cuernavaca, Mexico.
Nuno LunetEPIUnit, Instituto de Saúde Pública da Universidade Do Porto, Porto, Portugal.
Samantha MoraisEPIUnit, Instituto de Saúde Pública da Universidade Do Porto, Porto, Portugal.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, Moscow, Russia.
Dmitry MaximovichDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, Moscow, Russia.
Vicente MartínConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Gemma Castano-VinyalsConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Jesús VioqueConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Sandra González-PalaciosConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Mary H WardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Reza MalekzadehDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza PaksereshtDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Raul Ulises Hernández-RamirezDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Malaquias López-CervantesFacultad de Medicina, National Autonomous University of Mexico (UNAM), Coyoacán, Mexico.
Eva NegriDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Federica TuratiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Shoichiro TsuganeDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Akihisa HidakaDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Areti LagiouDepartment of Public and Community Health, School of Public Health, University of West Attica, Athens, Greece.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
M Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Maria Paula CuradoCentro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brasil.
Stefania BocciaSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italia.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy. paolo.boffetta@unibo.it.ORCID 0000-0002-3811-2791
University of Milan · ITNational Institutes of Health · USUniversity of Bologna · ITUniversidade do Porto · PTUniversitat de Miguel Hernández d'Elx · ESAC Camargo Hospital · BRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESHarvard University · USInstituto Nacional de Salud Pública · MXInternational University of Health and Welfare · JPPeking University · CNPiedmont Reference Center for Epidemiology and Cancer Prevention · ITStony Brook School · USTehran University of Medical Sciences · IRTokyo Yamate Medical Center · JPUCLA Health · USUniversidad Nacional Autónoma de México · MXUniversità Cattolica del Sacro Cuore · ITUniversitat Pompeu Fabra · ESUniversity of Leeds · GB

Funding

Associazione Italiana per la Ricerca sul Cancro 21378Division of Cancer Epidemiology and Genetics, National Cancer Institute Intramural Research ProgramEuropean Cancer Prevention Organization European Cancer Prevention OrganizationFEDER PTDC/SAU-EPI/32358/2017Fundação para a Ciência e a Tecnologia UIDB/04750/2020Instituto De Saúde Pública, Universidade do Porto UIDP/04750/2020Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional LA/P/0064/2020Ministero della Salute RF-2021-12373951
6 · The paper itself

Abstract

backgroundPrevious studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC.

methodsFourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.

resultsIndividuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0.

conclusionsThe findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).

Indexed as

Ascorbic AcidStomach NeoplasmsCase-Control StudiesDietEatingFemaleFruitHumansMaleRisk FactorsVegetablesAscorbic AcidCase–controlConsortiumDietGastric cancerPooled analysisVitamin C

Identifiers

PMID38436761
PMCPMC11016516
OpenAlexW4392369368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.