Evidence map›Paper›PMID 38436304›Full record

ArticleeLife2024

Heterosynaptic plasticity of the visuo-auditory projection requires cholecystokinin released from entorhinal cortex afferents.

Wenjian Sun, Haohao Wu, Yujie Peng, Xuejiao Zheng, Jing Li, Dingxuan Zeng, Peng Tang, Ming Zhao, Hemin Feng, Hao Li and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. mGluR5 in ECAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Wenjian Sun *Department of Neuroscience, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0003-1584-8242
Haohao Wu *Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Yujie Peng *Department of Neuroscience, City University of Hong Kong, Hong Kong, China.
Xuejiao Zheng *Department of Neuroscience, City University of Hong Kong, Hong Kong, China.
Jing Li *Department of Neuroscience, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0001-8075-0650
Dingxuan Zeng *Department of Neuroscience, City University of Hong Kong, Hong Kong, China.
Peng TangDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.
Ming ZhaoDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Hemin FengDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.
Hao LiDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.
Ye LiangDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.
Junfeng SuDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.
Xi ChenDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0002-2144-6584
Tomas HökfeltDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jufang HeDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0002-4288-5957
City University of Hong Kong · HKKarolinska Institutet · SE

Funding

Hong Kong health bureau Health and Medical Research Fund,06172456Hong Kong health bureau Health and Medical Research Fund,09203656Hong Kong Health Bureau Health and Medical Research Fund 06172456Hong Kong Health Bureau Health and Medical Research Fund 09203656Hong Kong Innovation and Technology Commission Innovation and Technology Fund GHP_075_19GDHong Kong Innovation and Technology Commission Innovation and Technology Fund,GHP_075_19GDHong Kong Innovation and Technology Commission Innovation and Technology Fund MRP/053/18XHong Kong Innovation and Technology Commission Innovation and Technology Fund,MRP/053/18XHong Kong Research Grants Council Collaborative Research Fund C1043-21GFHong Kong Research Grants Council Collaborative Research Fund,C1043-21GFHong Kong Research Grants Council General Research Fund 11101521MHong Kong Research Grants Council General Research Fund,11101521MHong Kong Research Grants Council General Research Fund 11103220MHong Kong Research Grants Council General Research Fund,11103220MKey Area Research and Development Program of Guangdong Province 2018B030340001Key-Area Research and Development Program of Guangdong Province 2018B030340001Swedish Research Council 2018-0273Swedish Research Council 220-01688The Swedish Research Council 2018-0273The Swedish Research Council 220-01688
6 · The paper itself

Abstract

The entorhinal cortex is involved in establishing enduring visuo-auditory associative memory in the neocortex. Here we explored the mechanisms underlying this synaptic plasticity related to projections from the visual and entorhinal cortices to the auditory cortex in mice using optogenetics of dual pathways. High-frequency laser stimulation (HFS laser) of the visuo-auditory projection did not induce long-term potentiation. However, after pairing with sound stimulus, the visuo-auditory inputs were potentiated following either infusion of cholecystokinin (CCK) or HFS laser of the entorhino-auditory CCK-expressing projection. Combining retrograde tracing and RNAscope in situ hybridization, we show that

Indexed as

CholecystokininEntorhinal CortexAnimalsLong-Term PotentiationMiceNeuronal PlasticityNeuronsCholecystokininauditory cortexcross-modal associationHebbian plasticitylong-term potentiationmouseneuropeptidesneurosciencepre- and postsynaptic coactivityrat

Identifiers

PMID38436304
PMCPMC10954309
OpenAlexW4392378582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.