Evidence map›Paper›PMID 38435826›Full record

ReviewBioengineering & translational medicine2024

AI-organoid integrated systems for biomedical studies and applications.

Sudhiksha Maramraju, Andrew Kowalczewski, Anirudh Kaza, Xiyuan Liu, Jathin Pranav Singaraju, Mark V Albert, Zhen Ma, Huaxiao Yang

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
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  7. Mesoscale maladaptation in disease organoids.Disease models & mechanisms · 2026
    Article
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  18. Biomaterials in organoid research: current state and future directions.Frontiers in bioengineering and biotechnology · 2026
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sudhiksha MaramrajuDepartment of Biomedical Engineering University of North Texas Denton Texas USA.
Andrew KowalczewskiDepartment of Biomedical & Chemical Engineering Syracuse University Syracuse New York USA.
Anirudh KazaDepartment of Biomedical Engineering University of North Texas Denton Texas USA.
Xiyuan LiuDepartment of Mechanical & Aerospace Engineering Syracuse University Syracuse New York USA.
Jathin Pranav SingarajuDepartment of Biomedical Engineering University of North Texas Denton Texas USA.
Mark V AlbertDepartment of Biomedical Engineering University of North Texas Denton Texas USA.
Zhen MaDepartment of Biomedical & Chemical Engineering Syracuse University Syracuse New York USA.
Huaxiao YangDepartment of Biomedical Engineering University of North Texas Denton Texas USA.ORCID https://orcid.org/0000-0001-9335-8201
University of North Texas · USLiving Systems (United States) · USSyracuse University · US

Funding

Establishing an In Vitro Embryotoxicity Risk Classification System Based on Human Cardiac Organoid ModelR01HD101130 · NICHD · SYRACUSE UNIVERSITY · PI MA, ZHEN · 2020 to 2025
$2.3M
NOTCH signaling on the underdeveloped cardiac vascularization of hypoplastic left heart syndrome in the hiPSC-derived vascularized cardiac organoidsR15HD108720 · NICHD · UNIVERSITY OF NORTH TEXAS · PI YANG, HUAXIAO · 2022 to 2022
$438k
NICHD NIH HHS R01 HD101130NICHD NIH HHS R15 HD108720
6 · The paper itself

Abstract

In this review, we explore the growing role of artificial intelligence (AI) in advancing the biomedical applications of human pluripotent stem cell (hPSC)-derived organoids. Stem cell-derived organoids, these miniature organ replicas, have become essential tools for disease modeling, drug discovery, and regenerative medicine. However, analyzing the vast and intricate datasets generated from these organoids can be inefficient and error-prone. AI techniques offer a promising solution to efficiently extract insights and make predictions from diverse data types generated from microscopy images, transcriptomics, metabolomics, and proteomics. This review offers a brief overview of organoid characterization and fundamental concepts in AI while focusing on a comprehensive exploration of AI applications in organoid-based disease modeling and drug evaluation. It provides insights into the future possibilities of AI in enhancing the quality control of organoid fabrication, label-free organoid recognition, and three-dimensional image reconstruction of complex organoid structures. This review presents the challenges and potential solutions in AI-organoid integration, focusing on the establishment of reliable AI model decision-making processes and the standardization of organoid research.

Indexed as

artificial intelligencedeep learningdisease modelingdrug evaluationhuman pluripotent stem cells (hPSCs)machine learningorganoidregenerative medicine

Identifiers

PMID38435826
PMCPMC10905559
OpenAlexW4391044901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.