ArticleBioengineering & translational medicine2024
Hydraulic conductivity of human cancer tissue: A hybrid study.
Article in Bioengineering & translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- A Modular Computational Approach for Assessing Active and Passive Force Contributions in Interstitial Lymphatic Fluid Uptake.Annals of biomedical engineering · 2026Article
- Fracking in Tumors: A Key Drug Transport Mechanism.Annals of biomedical engineering · 2026Article
- Modeling Thixotropic Hydrogel Carriers to Limit Healthy-Tissue Exposure via Localized Drug Retention in Chemotherapy.Polymers · 2026Article
- Mechanistic model of phase-transitioning therapeutics injected into poroelastic tissue for improved targeting of superficial tumors.Scientific reports · 2026Article
- Mechanistic model of phase-transitioning therapeutics injected into poroelastic tissue for improved targeting of superficial tumors.Research square · 2025Article
- Evaluation of Flow-Induced Shear in a Porous Microfluidic Slide: CFD Analysis and Experimental Investigation.Fluids (Basel, Switzerland) · 2025Article
- Computational Evaluation of Improved HIPEC Drug Delivery Kinetics via Bevacizumab-Induced Vascular Normalization.Pharmaceutics · 2025Article
- The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming.Scientific reports · 2025Article
- Hydraulic conductivity of human cancer tissue: A hybrid study.Bioengineering & translational medicine · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and an aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IFP non-invasively. Image-based estimation of the IFP requires knowledge of the tissue hydraulic conductivity ( Methods: We measured the hydraulic conductivity of tumor tissue using modified Ussing chambers in surgical resection specimens. The effect of the tumor microenvironment (TME) on Results: The results show that the hydraulic conductivity of human tumor tissues is very limited, ranging from approximately 10 Conclusions: Human tumor tissue is characterized by a very limited hydraulic conductivity, representing a barrier to effective drug transport. The results of this study can inform the development of realistic computational models, facilitate non-invasive IFP estimation, and contribute to stromal targeting anticancer therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.