Evidence map›Paper›PMID 38435710›Full record

Article... International Conference on Sampling Theory and Applications (SampTA). International Conference on Sampling Theory and Applications2023

On Manifold Learning in Plato's Cave: Remarks on Manifold Learning and Physical Phenomena.

Roy R Lederman, Bogdan Toader

Abstract read
In one paragraph

Article in ... International Conference on Sampling Theory and Applications (SampTA). International Conference on Sampling Theory and Applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. MANIFOLD LEARNING IN METRIC SPACES.Applied and computational harmonic analysis · 2026
    Article
  2. Amortized template matching of molecular conformations from cryoelectron microscopy images using simulation-based inference.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Cryo-EM heterogeneity analysis using regularized covariance estimation and kernel regression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Roy R LedermanDepartment of Statistics and Data Science, Yale University, New Haven, Connecticut, USA.
Bogdan ToaderDepartment of Statistics and Data Science, Yale University, New Haven, Connecticut, USA.

Funding

Reconstruction of heterogeneous and small macromolecules by cyro-EMR01GM136780 · NIGMS · PRINCETON UNIVERSITY · PI SINGER, AMIT · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM136780
6 · The paper itself

Abstract

Many techniques in machine learning attempt explicitly or implicitly to infer a low-dimensional manifold structure of an underlying physical phenomenon from measurements without an explicit model of the phenomenon or the measurement apparatus. This paper presents a cautionary tale regarding the discrepancy between the geometry of measurements and the geometry of the underlying phenomenon in a benign setting. The deformation in the metric illustrated in this paper is mathematically straightforward and unavoidable in the general case, and it is only one of several similar effects. While this is not always problematic, we provide an example of an arguably standard and harmless data processing procedure where this effect leads to an incorrect answer to a seemingly simple question. Although we focus on manifold learning, these issues apply broadly to dimensionality reduction and unsupervised learning.

Identifiers

PMID38435710
PMCPMC10903505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.