Evidence map›Paper›PMID 38435669›Full record

ArticleFrontiers in chemistry2024

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via

Syed Mohd Danish Rizvi, Ibrahim A Almazni, Mamdoh S Moawadh, Zeyad M Alharbi, Nawal Helmi, Leena S Alqahtani, Talib Hussain, Ahmed Alafnan, Afrasim Moin, AbdElmoneim O Elkhalifa and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. SoloxoloneMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Syed Mohd Danish RizviDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Ibrahim A AlmazniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia.
Mamdoh S MoawadhDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Zeyad M AlharbiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Nawal HelmiDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Leena S AlqahtaniDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Talib HussainDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Ahmed AlafnanDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Afrasim MoinDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
AbdElmoneim O ElkhalifaDepartment of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Ha'il, Saudi Arabia.
Amir Mahgoub AwadelkareemDepartment of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Ha'il, Saudi Arabia.
Mohammad KhalidDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Rohit Kumar TiwariDepartment of Clinical Research, Sharda School of Allied Health Sciences, Sharda University, Gautam Budh Nagar, India.
University of Ha'il · SAUniversity of Jeddah · SAUniversity of Tabuk · SANajran University · SAPrince Sattam Bin Abdulaziz University · SASharda University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a naturally derived benzophenone, was assessed against GBM. During the analysis, we observed a reduction in the viability of rat glioblastoma C6 cells at a concentration of 30 µM of the extract (

Indexed as

anti-cancerbenzophenonegarcinolglioblastoma multiformeNF-κB

Identifiers

PMID38435669
PMCPMC10904546
OpenAlexW4391880269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.