Evidence map›Paper›PMID 38435639›Full record

ArticleMethodsX2024

Effect of high-definition transcranial direct current stimulation among late-subacute and chronic stroke survivors with fatigue: A randomized-controlled crossover trial protocol.

Akhila Jagadish, Manikandan Natarajan, Divya Bharatkumar Adhia, Annapoorna Kuppuswamy, Vasudeva Guddattu, John M Solomon

Registry-linked trialAbstract read
In one paragraph

Article in MethodsX, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06999876 (The Effect of Combined Transcranial Pulse Current Stimulation), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06999876 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia: A Double-blind, Sham-controlled, Randomized Controlled Study

TypeinterventionalSponsorNational University Health System, SingaporeRan2025 to 2026Enrolled90ConditionsStroke Patients With Hemiplegia or Hemiparesis in the Subacute StageArmsThe AscenZ-VIII Stimulator (Investigational Medical Device)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Neuroimmune Mechanisms and Emerging Intervention Strategies for Post-Stroke Fatigue: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akhila JagadishDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Manikandan NatarajanDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Divya Bharatkumar AdhiaDepartment of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin 9013, New Zealand.
Annapoorna KuppuswamyDepartment of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Vasudeva GuddattuDepartment of Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
John M SolomonDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-stroke fatigue (PSF) is a commonly overlooked symptom that impacts daily functioning and quality of life. It is caused by altered functional connectivity within the brain networks, which can potentially be influenced by neuromodulation. Multiple cortical regions have been targeted to reduce PSF, but the most efficient ones remain uncertain. Therefore, we aim to identify the most appropriate cortical stimulation site to reduce PSF. Twenty participants with PSF will be included in this cross-over trial. Each participant will receive one session of active anodal high definition- transcranial direct current stimulation (HD-tDCS) over three different cortical areas and one session of sham tDCS in a cross-over manner, with a two-week of washout period in between. Pre- and post- fatigue will be assessed using Fatigue Severity Scale and fatigability using electromyography by determining the time to task failure. Resting-state electroencephalography will be performed before and after each stimulation session to determine the functional connectivity of the cortical areas stimulated.

Indexed as

ElectroencephalographyNeuromodulationPoststroke fatigueRandomized-controlled crossover trial protocolStrokeTranscranial direct current stimulation

Identifiers

PMID38435639
PMCPMC10907195

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.