Evidence map›Paper›PMID 38435455›Full record

ArticleNeurobiology of disease2023

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2.

Dylan J Dues, Yue Ma, An Phu Tran Nguyen, Alina V Offerman, Ian Beddows, Darren J Moore

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. LRRK2 as a Potential Disease-Modifying Target in Sporadic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dylan J DuesDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
Yue MaDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
An Phu Tran NguyenDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
Alina V OffermanDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
Ian BeddowsDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Darren J MooreDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
Van Andel Institute · US

Funding

Alpha-Synuclein Induced Network Hyperexcitability in Lewy Body DementiasR56AG074473 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, MICHAEL K, MOORE, DARREN JOHN · 2021 to 2021
$840k
NIA NIH HHS R56 AG074473
6 · The paper itself

Abstract

Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein share enigmatic roles in the pathobiology of Parkinson's disease (PD).

Indexed as

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseSynucleinopathiesalpha-SynucleinAnimalsDisease Models, AnimalMiceMice, KnockoutProsencephalonalpha-SynucleinLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk2 protein, mouseAlpha-synucleinAnimal modelsLewy bodyLRRK2MicrogliaNeurodegenerationParkinson’s diseaseProtein aggregation

Identifiers

PMID38435455
PMCPMC10906965
OpenAlexW4388006712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.