Evidence map›Paper›PMID 38434836›Full record

ArticleACS omega2024

Enhancement of Vitamin C's Protective Effect against Thimerosal-Induced Neurotoxicity in the Cerebral Cortex of Wistar Albino Rats: An

Amr Hassan, Reham Mohsen, Ahmed Rezk, Gabrielle Bangay, Patrícia Rijo, Mona F M Soliman, Mohamed G A Hablas, Khalifa AbdulRazik K Swidan, Tahseen S Mohammed, Mohammad A Zoair and 7 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Frontiers in pharmacology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Amr HassanDepartment of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat 32897, Egypt.ORCID https://orcid.org/0000-0001-6623-2179
Reham MohsenCollege of Biotechnology, October University for Modern Science and Arts (MSA), University Giza, Giza 11456, Egypt.
Ahmed RezkCollege of Biotechnology, October University for Modern Science and Arts (MSA), University Giza, Giza 11456, Egypt.
Gabrielle BangayCBIOS-Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Lisboa 1749-024, Portugal.
Patrícia RijoCBIOS-Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Lisboa 1749-024, Portugal.ORCID https://orcid.org/0000-0001-7992-8343
Mona F M SolimanDepartment of Histology and Cell Biology, Faculty Medicine, Mansoura University, Mansoura 35516, Egypt.
Mohamed G A HablasDepartment of Histology and Cell Biology, Faculty of Medicine, Suez University, Suez 43221, Egypt.
Khalifa AbdulRazik K SwidanDepartment of Histology and Cell Biology, Faculty of Medicine, Suez University, Suez 43221, Egypt.
Tahseen S MohammedDepartment of Public Health and Community Medicine, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Mohammad A ZoairDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Abir A Khalil MohamedDepartment of Zoology, Faculty of Science, Girls Branch, Al-Azhar University, Cairo 11884, Egypt.
Tamer I AbdalrhmanDepartment of Histology, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Ahmad M Abdel-Aleem DesokyDepartment of Histology, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Dalia D MohamedDepartment of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat 32897, Egypt.
Doaa D MohamedDepartment of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat 32897, Egypt.
Ahmed I Abd El MaksoudDepartment of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat 32897, Egypt.
Aly F MohamedHolding Company for Vaccine and Sera Production (VACSERA), Giza 22311, Egypt.
Al-Azhar University · EGUniversity of Sadat City · EGOctober University of Modern Sciences and Arts · EGSuez University · EGMansoura University · EGUniversidad de Alcalá · ESUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin C was examined to ameliorate the neurotoxicity of thimerosal (THIM) in an animal model (Wistar albino rats). In our work, oxidative and antioxidative biomarkers such as SOD, LPO, and GSH were investigated at various doses of THIM with or without concurrent vitamin C administration. Furthermore, the adverse effects of THIM on hepatic tissue and cerebral cortex morphology were examined in the absence or presence of associated vitamin C administration. Also, we studied the effect of vitamin C on the metallothionein isoforms (MT-1, MT-2, and MT-3)

Identifiers

PMID38434836
PMCPMC10905602
OpenAlexW4391874643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.