Evidence map›Paper›PMID 38434760›Full record

ArticleMedComm2024

Induction immunochemotherapy followed by definitive chemoradiotherapy for unresectable locally advanced non-small cell lung cancer: a multi-institutional retrospective cohort study.

Leilei Wu, Bo Cheng, Xiaojiang Sun, Zhenshan Zhang, Jingjing Kang, Yun Chen, Qinghua Xu, Shuangyan Yang, Yujie Yan, Shengxiang Ren and 2 more

Abstract read
In one paragraph

Article in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Leilei WuDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.ORCID https://orcid.org/0000-0003-0060-2012
Bo ChengDepartment of Radiation Oncology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan China.
Xiaojiang SunDepartment of Radiation Oncology Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) Institute of Cancer and Basic Medicine (IBMC) Chinese Academy of Sciences Hangzhou China.
Zhenshan ZhangDepartment of Radiation Oncology Shanghai Proton and Heavy Ion Center Fudan University Cancer Hospital Shanghai China.ORCID https://orcid.org/0000-0002-6846-4464
Jingjing KangDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Yun ChenDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Qinghua XuDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Shuangyan YangDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Yujie YanDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Shengxiang RenDepartment of Medical Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Caicun ZhouDepartment of Medical Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.
Yaping XuDepartment of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai China.ORCID https://orcid.org/0009-0002-9109-1958

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the efficacy and safety of induction immunochemotherapy followed by definitive chemoradiotherapy (CRT) for unresectable locally advanced non-small cell lung cancer (LA-NSCLC). We identified unresectable stage III NSCLC patients who received induction immunochemotherapy. Overall survival (OS) and progression-free survival (PFS) were the primary endpoints. From February 2019 to August 2022, 158 patients were enrolled. Following the completion of induction immunochemotherapy, the objective response rate (ORR) and disease control rate (DCR) were 52.5% and 83.5%, respectively. The ORR of CRT was 73.5%, representing 68.4% of the total cohort. The median PFS was 17.8 months, and the median OS was 41.9 months, significantly higher than in patients who received CRT alone (

Indexed as

definitive chemoradiotherapyInduction immunochemotherapysurvivalunresectable LA‐NSCLC

Identifiers

PMID38434760
PMCPMC10908364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.