Evidence map›Paper›PMID 38434522›Full record

ArticleHemaSphere2024

Exploring the molecular biomarker utility of circCCT3 in multiple myeloma: A favorable prognostic indicator, particularly for R-ISS II patients.

Maria Papatsirou, Christos K Kontos, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Diamantis C Sideris, Despina Fotiou, Christine-Ivy Liacos, Maria Gavriatopoulou, Efstathios Kastritis, Meletios A Dimopoulos and 2 more

Abstract read
In one paragraph

Article in HemaSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. The therapeutic potential of circular RNAs.Nature reviews. Genetics · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria PapatsirouDepartment of Biochemistry and Molecular Biology, Faculty of Biology National and Kapodistrian University of Athens Athens Greece.
Christos K KontosDepartment of Biochemistry and Molecular Biology, Faculty of Biology National and Kapodistrian University of Athens Athens Greece.
Ioannis Ntanasis-StathopoulosDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Panagiotis MalandrakisDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Diamantis C SiderisDepartment of Biochemistry and Molecular Biology, Faculty of Biology National and Kapodistrian University of Athens Athens Greece.
Despina FotiouDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Christine-Ivy LiacosDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Maria GavriatopoulouDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Efstathios KastritisDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Meletios A DimopoulosDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.
Andreas ScorilasDepartment of Biochemistry and Molecular Biology, Faculty of Biology National and Kapodistrian University of Athens Athens Greece.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.ORCID 0000-0001-5133-1422

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are associated with the pathobiology of multiple myeloma (MM). Recent findings regarding circCCT3 support its involvement in the development and progression of MM, through microRNA sponging. Thus, we aimed to examine the expression of circCCT3 in smoldering and symptomatic MM and to assess its clinical importance. Three cell lines from plasma cell neoplasms were cultured and bone marrow aspirate (BMA) samples were collected from 145 patients with MM or smoldering MM. Next, CD138

Identifiers

PMID38434522
PMCPMC10878196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.