ArticleHeliyon2024
Effects of temperature anomaly on sperm quality: A multi-center study of 33,234 men.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Heat exposure during susceptible windows of spermatogenesis and sperm epigenetic age.Human reproduction (Oxford, England) · 2026Trial
- The association between extreme heat and sperm quality in a chronically heat-exposed population: An observational study in Singapore.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Climate change and sexual and reproductive health: A mixed methods scoping review of possible mechanisms.iScience · 2026Review
- Recovery of male DNA acquired from carrion-feeding insects in a simulated sexual assault scenario.Journal of forensic sciences · 2026Article
- Global Warming, Fertility, and Spermatogenesis Decline: Global and Regional Evidence from 195 Countries and Implications for Climate Adaptation Policy.International journal of environmental research and public health · 2026Article
- Environmental and microbiome determinants of sperm quality: a narrative review on male health.Translational andrology and urology · 2026Review
- Particulate exposure during spermatogenesis is associated with adverse bull reproductive fitness in a wildfire impacted area.Journal of animal science · 2026Article
- Heat shock proteins in male infertility: recent advances and clinical implications.Frontiers in cell and developmental biology · 2026Review
- Environmental determinants of male infertility: emerging threats and technological interventions.Frontiers in medicine · 2026Review
- Urology on a changing planet: links between climate change and urological disease.Nature reviews. Urology · 2025Review
- Ambient climatic conditions and semen quality: a comparative analysis across the periods before, during, and after the COVID-19 pandemic.Frontiers in endocrinology · 2025Article
- Effects of Heat Stress-Induced Sex Hormone Dysregulation on Reproduction and Growth in Male Adolescents and Beneficial Foods.Nutrients · 2024Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Backgrounds: Global fertility rates continue to decline and sperm quality is a prime factor affecting male fertility. Both extreme cold and heat have been demonstrated to be associated with decreased sperm quality, but no epidemiological studies have considered human adaptation to long-term temperature. Our aim was to conduct a multi-center retrospective cohort study to investigate exposure-response relationship between temperature anomaly (TA) that deviate from long-term climate patterns and sperm quality. Methods: A total of 78,952 semen samples measured in 33,234 donors from 6 provincial human sperm banks in China were collected. This study considered heat and cold acclimatization to prolonged exposure in humans and explored the exposure-response relationship between TAs and sperm quality parameters (sperm concentrations, sperm count, progressive motility, progressive sperm count, total motility and total motile sperm count) during the hot and cold seasons, respectively. Linear mixed models and generalized linear models were built separately for specific centers to pool in a meta-analysis to obtain the pooled effect of TA on sperm quality, considering repeated measurements data structure and spatial heterogeneity. Results: We identified an inverted U-shaped exposure-response relationship between TA and sperm quality during the hot season. Significant negative effect of anomalous cold on sperm quality during the hot season was found after additional adjustment for Body mass index, marital status and childbearing history. The heat-related TA in hot season was significantly negatively associated with sperm concentration, progressive sperm count and total motile sperm count (all Conclusions: Our results suggest both heat-related and cold-related TAs are associated with decreased sperm quality. The findings highlight the importance of reducing exposure to anomalous temperatures to protect male fertility.
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