Evidence map›Paper›PMID 38433822›Full record

ArticleFrontiers in bioengineering and biotechnology2024

Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing.

Brendan Y Shi, Varun Sriram, Shannon Y Wu, Dave Huang, Alexis Cheney, Melodie F Metzger, Oskar Sundberg, Karen M Lyons, Charles E McKenna, Ichiro Nishimura and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brendan Y ShiDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Varun SriramDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Shannon Y WuDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Dave HuangDepartment of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Alexis CheneyDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Melodie F MetzgerDepartment of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Oskar SundbergDepartment of Chemistry, University of Southern California, Los Angeles, CA, United States.
Karen M LyonsDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Charles E McKennaDepartment of Chemistry, University of Southern California, Los Angeles, CA, United States.
Ichiro NishimuraWeintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California at Los Angeles, Los Angeles, CA, United States.
Thomas J KremenDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
Multiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599k
Enhanced Soft Tissue-to-Bone Healing via Treatment with Novel Growth Factor NELL-1: Targeted Delivery and Biomimetic ScaffoldsIK2BX005199 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI THOMAS John KREMEN · 2020 to 2026
–
BLRD VA IK2 BX005199NCATS NIH HHS UL1 TR001881NIAMS NIH HHS T32 AR059033NIH HHS S10 OD025017
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomechanicsenthesisgrowth factor deliveryrotator cuff repairtargeted delivery

Identifiers

PMID38433822
PMCPMC10905384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.