Evidence map›Paper›PMID 38433744›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Incidence of young-onset dementia in Italy: The Brescia register study.

Barbara Borroni, Ilenia Libri, Matteo Rota, Giuliano Binetti, Luisa Benussi, Roberta Ghidoni, Maria Sofia Cotelli, Silvia Fostinelli, Fabio Guerini, Stefano Boffelli and 10 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Barbara BorroniDepartment of Clinical and Experimental Sciences University of Brescia Brescia Italy.
Ilenia LibriDepartment of Clinical and Experimental Sciences University of Brescia Brescia Italy.
Matteo RotaDepartment of Molecular and Translational Medicine University of Brescia Brescia Italy.
Giuliano BinettiMemory Clinic IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy.
Luisa BenussiMolecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy.
Roberta GhidoniMolecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy.
Maria Sofia CotelliNeurology Unit, ASST Vallecamonica Brescia Italy.
Silvia FostinelliMemory Clinic IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy.
Fabio GueriniMedicine and Rehabilitative Unit, Sant'Anna Institute Brescia Italy.
Stefano BoffelliPoliambulanza Foundation Hospital Brescia Italy.
Eugenio MagniPoliambulanza Foundation Hospital Brescia Italy.
Marta PengoNeurology Unit, "Città di Brescia" Hospital Brescia Italy.
Michele GennusoNeurology Unit, "Città di Brescia" Hospital Brescia Italy.
Marta BianchiNeurology Unit, ASST Vallecamonica Brescia Italy.
Beatrice CossuMedicine Unit, ASST Franciacorta Chiari Brescia Italy.
Vincenzo PalombaNeurology ASST del Garda, Desenzano del Garda Brescia Italy.
Andrea CrucittiMedicine ASST del Garda Desenzano del Garda Brescia Italy.
Angelo BianchettiMedicine and Rehabilitative Unit, Sant'Anna Institute Brescia Italy.
Giancarlo LogroscinoCenter for Neurodegenerative Diseases and the Aging Brain Department of Clinical Research in Neurology University of Bari "Aldo Moro " Pia Fondazione Cardinale G. Panico Tricase Lecce Italy.
Alessandro PadovaniDepartment of Clinical and Experimental Sciences University of Brescia Brescia Italy.
University of Brescia · ITCentro San Giovanni di Dio Fatebenefratelli · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITCasa di Cura Villa Garda · ITFondazione Poliambulanza Istituto Ospedaliero · ITOspedale Sant'Anna · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young-onset dementia [YOD]) and define the frequencies of young-onset Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and dementia with Lewy bodies (DLB) in the general population.

methodsThe study was conducted from January 1, 2019 to December 31, 2019 in Brescia province (population: 1,268,455). During the study period, all new YOD cases (incident YOD) were counted, and all patients' records reviewed. The incidence was standardized to the Italian general population in 2019.

resultsA total of 29 YOD patients were diagnosed. The age-sex standardized incidence rate was 4.58 (95% confidence interval, 3.07-6.58) per 100,000 person-years. No difference in incidence rate between YOD due to AD or FTLD ( DISCUSSION: Presenting neurodegenerative YOD phenotypes encompasses both AD and FTLD. Improved knowledge on YOD epidemiology is essential to adequately plan and organize health services.

Indexed as

Alzheimer's diseasefrontotemporal dementiaincidencepopulation‐based studyyoung‐onset dementia

Identifiers

PMID38433744
PMCPMC10904882
OpenAlexW4392397970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.