Evidence map›Paper›PMID 38433721›Full record

ArticleThe Journal of pathology2024

AI-guided histopathology predicts brain metastasis in lung cancer patients.

Haowen Zhou, Mark Watson, Cory T Bernadt, Steven Siyu Lin, Chieh-Yu Lin, Jon H Ritter, Alexander Wein, Simon Mahler, Sid Rawal, Ramaswamy Govindan and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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  13. Translational lung cancer research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Haowen Zhou *Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-0955-4010
Mark Watson *Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Cory T BernadtDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Steven Siyu LinDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Chieh-Yu LinDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Jon H RitterDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Alexander WeinDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Simon MahlerDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-9761-445X
Sid RawalDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Ramaswamy GovindanDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Changhuei YangDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Richard J CoteDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Washington University in St. Louis · USCalifornia Institute of Technology · US

Funding

A comprehensive liquid biopsy platform for detection and prognostication in early stage breast cancerU01CA233363 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AGARWAL, ASHUTOSH, COTE, RICHARD JAMES · 2018 to 2022
$2.6M
GENOMIC HARBINGERS OF BRAIN METASTASIS IN NON SMALL CELL LUNG CANCERR01CA182746 · NCI · WASHINGTON UNIVERSITY · PI GOVINDAN, RAMASWAMY, WATSON, MARK A. · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA182746NCI NIH HHS U01 CA233363NCI NIH HHS U01CA233363
6 · The paper itself

Abstract

Brain metastases can occur in nearly half of patients with early and locally advanced (stage I-III) non-small cell lung cancer (NSCLC). There are no reliable histopathologic or molecular means to identify those who are likely to develop brain metastases. We sought to determine if deep learning (DL) could be applied to routine H&E-stained primary tumor tissue sections from stage I-III NSCLC patients to predict the development of brain metastasis. Diagnostic slides from 158 patients with stage I-III NSCLC followed for at least 5 years for the development of brain metastases (Met

Indexed as

Brain NeoplasmsCarcinoma, Non-Small-Cell LungLung NeoplasmsAlgorithmsHumansPathologistsartificial intelligencebrain metastasisdeep learningdigital pathologynon‐small cell lung cancer

Identifiers

PMID38433721
PMCPMC11210939
OpenAlexW4392374249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.