Evidence map›Paper›PMID 38433665›Full record

ArticleHuman brain mapping2024

Optimising brain age estimation through transfer learning: A suite of pre-trained foundation models for improved performance and generalisability in a clinical setting.

David A Wood, Matthew Townend, Emily Guilhem, Sina Kafiabadi, Ahmed Hammam, Yiran Wei, Ayisha Al Busaidi, Asif Mazumder, Peter Sasieni, Gareth J Barker and 3 more

Abstract read
In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Increased Brain-Age Gap in Young Adults With Psychotic Experiences.Biological psychiatry global open science · 2026
    Article
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  4. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David A WoodSchool of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, London, UK.ORCID 0000-0003-3058-4871
Matthew TownendSchool of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, London, UK.
Emily GuilhemKing's College Hospital NHS Foundation Trust, London, UK.
Sina KafiabadiKing's College Hospital NHS Foundation Trust, London, UK.
Ahmed HammamKing's College Hospital NHS Foundation Trust, London, UK.
Yiran WeiSchool of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, London, UK.
Ayisha Al BusaidiKing's College Hospital NHS Foundation Trust, London, UK.
Asif MazumderGuy's and St Thomas' NHS Foundation Trust, London, UK.
Peter SasieniSchool of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, London, UK.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Sebastien OurselinSchool of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, London, UK.
James H ColeDementia Research Centre, Institute of Neurology, University College London, London, UK.ORCID 0000-0003-1908-5588
Thomas C BoothSchool of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, London, UK.

Funding

Medical Research Council MR/R024790/1Medical Research Council MR/R024790/2Medical Research Council MR/W021684/1Wellcome TrustWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

Estimated age from brain MRI data has emerged as a promising biomarker of neurological health. However, the absence of large, diverse, and clinically representative training datasets, along with the complexity of managing heterogeneous MRI data, presents significant barriers to the development of accurate and generalisable models appropriate for clinical use. Here, we present a deep learning framework trained on routine clinical data (N up to 18,890, age range 18-96 years). We trained five separate models for accurate brain age prediction (all with mean absolute error ≤4.0 years, R

Indexed as

BrainMental RecallAdolescentAdultAgedAged, 80 and overChild, PreschoolDiffusionHumansMachine LearningMiddle AgedNeuroimagingYoung Adultbrain agedeep learningfoundation modelMRItransfer learning

Identifiers

PMID38433665
PMCPMC10910262

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.