Evidence map›Paper›PMID 38433559›Full record

ArticleMolecular genetics & genomic medicine2024

Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency.

Xiao-Liang Xing, Ziqiang Zeng, Yana Wang, Bo Pan, Xueshuang Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xiao-Liang XingSchool of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Ziqiang ZengSchool of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.ORCID https://orcid.org/0000-0001-8714-1583
Yana WangSchool of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Bo PanDepartment of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xueshuang HuangSchool of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.ORCID https://orcid.org/0000-0001-7622-8368
Hunan University of Traditional Chinese Medicine · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNNingxia Medical University · CN

Funding

Hunan Natural Science Foundation 2023JJ50442National Natural Science Foundation of China 31970556
6 · The paper itself

Abstract

backgroundHemifacial macrosomia (HFM, OMIM 164210) is a complex and highly heterogeneous disease. FORKHEAD BOX I3 (FOXI3) is a susceptibility gene for HFM, and mice with loss of function of Foxi3 did exhibit a phenotype similar to craniofacial dysmorphism. However, the specific pathogenesis of HFM caused by FOXI3 deficiency remains unclear till now.

methodIn this study, we first constructed a Foxi3 deficiency (Foxi3

resultsBy observing the phenotype of Foxi3

conclusionThe craniofacial dysmorphism caused by the deficiency of Foxi3 may be related to the expression of Akt2 and PI3K-Akt signaling pathway. This study laid a foundation for understanding the function of FOXI3 and the pathogenesis and treatment of related craniofacial dysmorphism caused by FOXI3 dysfunction.

Indexed as

Craniofacial AbnormalitiesMusculoskeletal AbnormalitiesAnimalsComputational BiologyForkhead Transcription FactorsMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktForkhead Transcription FactorsFoxi1 protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktcraniofacial dysmorphismFOXI3PI3K-Akt signaling pathway

Identifiers

PMID38433559
PMCPMC10910234
OpenAlexW4392370864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.