Evidence map›Paper›PMID 38433539›Full record

ArticleProblemy endokrinologii2024

[Primary Generalized Glucocorticoid Resistance: a case report].

I I Larina, N V Makazan, K V Ivashchenko, N M Platonova, E M Orlova, M A Kareva, L S Sozaeva, M Yu Yukina, A N Tulpakov, A S Dukhanin and 2 more

Open access · diamondAbstract readCase ReportsEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Problemy endokrinologii, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

I I LarinaEndocrinology Research Centre.
N V MakazanEndocrinology Research Centre.
K V IvashchenkoEndocrinology Research Centre.
N M PlatonovaEndocrinology Research Centre.
E M OrlovaEndocrinology Research Centre.
M A KarevaEndocrinology Research Centre.
L S SozaevaEndocrinology Research Centre.
M Yu YukinaEndocrinology Research Centre.
A N TulpakovResearch Centre for Medical Genetics.
A S DukhaninN.I. Pirogov Russian National Research Medical University.
N L ShimanovskiiN.I. Pirogov Russian National Research Medical University.
E A TroshinaN.I. Pirogov Russian National Research Medical University.
Endocrinology Research Center · RUPirogov Russian National Research Medical University · RUResearch Centre for Medical Genetics · RU

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Primary glucocorticoid resistance (OMIM 615962) is a rare endocrinologic condition caused by resistance of the human glucocorticoid receptor (hGR) to glucocorticoids (GR) and characterised by general or partial insensitivity of target organs to GK. Compensatory activation of hypothalamic-pituitary-andrenal axis results in development of a various pathological conditions caused by overstimulation of adrenal glands. Clinical spectrum may range from asymptomatic cases to severe cases of mineralocorticoid and/or androgen excess. At present time, primary generalized glucocorticoid resistance has been exclusively associated with defects in the NR3C1 gene. Here, we present a case report of an adolescent patient with clinical presentation of glucocorticoid resistance confirmed by detailed endocrinologic evaluation but no confirmed mutations in the NR3C1 gene.

Indexed as

Metabolism, Inborn ErrorsReceptors, GlucocorticoidAdolescentAdrenal GlandsGlucocorticoidsHumansRare DiseasesGlucocorticoidsReceptors, Glucocorticoid

Identifiers

PMID38433539
PMCPMC10926243
OpenAlexW4392296599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.