Evidence map›Paper›PMID 38433246›Full record

ArticleScientific reports2024

Occurrence and mechanisms of tigecycline resistance in carbapenem- and colistin-resistant Klebsiella pneumoniae in Thailand.

Nachat Chirabhundhu, Sirirat Luk-In, Thanawat Phuadraksa, Sineewanlaya Wichit, Tanittha Chatsuwan, Dhammika Leshan Wannigama, Sakda Yainoy

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. [Plasmid-mediated colistin resistance in pathogenic bacteria].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  9. Article
  10. Effect of sub-inhibitory tigecycline (½-MIC) on AcrAB-TolC andFrontiers in cellular and infection microbiology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. A 46-week outbreak of ertapenem-resistant, non-carbapenemase encodingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  15. Article
  16. Molecular Epidemiology and In-Depth Characterization ofInternational journal of molecular sciences · 2025
    Article
  17. Emergence ofCurrent research in microbial sciences · 2025
    Article
  18. Article
  19. Characterization ofFrontiers in cellular and infection microbiology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 4 countries.

Nachat Chirabhundhu *Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.
Sirirat Luk-In *Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.
Thanawat PhuadraksaDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.
Sineewanlaya WichitDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.
Tanittha ChatsuwanDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Dhammika Leshan WannigamaDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Sakda YainoyDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand. sakda.yai@mahidol.ac.th.
Mahidol University · THThai Red Cross Society · TH

Funding

Faculty of Medical Technology, Mahidol University graduate scholarship from the Master of Science Program in Medical Technology (International Program)Mahidol University Fundamental Fund: fiscal year 2023 by National Science Research and Innovation Fund (NSRF)National Research Council of Thailand N35A660013Thailand Research Fund (TRF) and the National Research Council of Thailand (NRCT). RSA6280021
6 · The paper itself

Abstract

Tigecycline has been regarded as one of the most important last-resort antibiotics for the treatment of infections caused by extensively drug-resistant (XDR) bacteria, particularly carbapenem- and colistin-resistant Klebsiella pneumoniae (C-C-RKP). However, reports on tigecycline resistance have been growing. Overall, ~ 4000 K. pneumoniae clinical isolates were collected over a five-year period (2017-2021), in which 240 isolates of C-C-RKP were investigated. Most of these isolates (91.7%) were resistant to tigecycline. Notably, a high-risk clone of ST16 was predominantly identified, which was associated with the co-harboring of bla

Indexed as

Carbapenem-Resistant EnterobacteriaceaeColistinAnti-Bacterial AgentsCarbapenemsKlebsiella pneumoniaeThailandTigecyclineAnti-Bacterial AgentsCarbapenemsColistinTigecycline

Identifiers

PMID38433246
PMCPMC10909888
OpenAlexW4392343286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.