ArticleInternal medicine (Tokyo, Japan)2024
Evidence of Tosufloxacin Deposition in the Kidneys of a Patient Presenting with Crystal Nephropathy.
Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- Acute kidney injury and urinary drug crystals in children treated with tosufloxacin: a multicenter retrospective study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Renal and gastrointestinal complications following tosufloxacin therapy for suspected mycoplasma infection in a 10-year-old child.CEN case reports · 2025Article
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9 authors at 3 institutions in 1 country.
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Abstract
Tosufloxacin tosilate is classified as a new quinolone antibacterial agent, which has been reported to cause crystal nephropathy. However, the origin of these crystal deposits has not yet been elucidated. We encountered a case of renal failure that progressed slowly owing to crystal-forming interstitial nephritis after long-term exposure to tosufloxacin. Mass spectrometry of the renal specimens revealed that tosufloxacin was deposited in the kidneys. The patient's renal function improved slowly with the withdrawal of tosufloxacin and steroid therapy. This is the first case to demonstrate the presence of crystal deposits consisting of tosufloxacin.
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