Evidence map›Paper›PMID 38432957›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Severe Acute Interstitial Nephritis Induced by α-glucosidase Inhibitor Miglitol in an Elderly Patient with Type 2 Diabetic Nephropathy.

Kazutoshi Ono, Takahiro Masuda, Yuko Ono, Erika Hishida, Hiromichi Yoshizawa, Toshimi Imai, Hiroshi Satonaka, Tetsu Akimoto, Daisuke Nagata

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kazutoshi OnoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Takahiro MasudaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Yuko OnoDepartment of Diagnostic Pathology, Dokkyo Medical University, Japan.
Erika HishidaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Hiromichi YoshizawaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Toshimi ImaiDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Hiroshi SatonakaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Tetsu AkimotoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Daisuke NagataDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Jichi Medical University · JPSocial Insurance Saitama Chuo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 79-year-old male patient with type 2 diabetic nephropathy and hypertension was admitted to our hospital because of acute kidney injury with significantly elevated serum creatinine (8.12 mg/dL) and urinary β2-microglobulin (β2MG, 31,748 μg/L) levels. α-glucosidase inhibitor (α-GI) miglitol, started two weeks prior to presentation, was discontinued because drug-induced acute interstitial nephritis (AIN) was suspected. Renal biopsy revealed AIN and diabetic nephropathy. The drug-induced lymphocyte stimulation test for miglitol was also positive. After the discontinuation of miglitol, the urinary β2MG levels decreased to the normal range. This case raises the possibility that α-GI miglitol can worsen the renal function in patients with underlying renal dysfunction.

Indexed as

1-DeoxynojirimycinDiabetes Mellitus, Type 2Diabetic NephropathiesGlycoside Hydrolase InhibitorsNephritis, InterstitialAcute DiseaseAcute Kidney InjuryAgedHumansMaleSeverity of Illness Index1-DeoxynojirimycinGlycoside Hydrolase Inhibitorsmiglitolacute interstitial nephritisdiabetic nephropathymiglitoltubular damage markerα-glucosidase inhibitorβ2-microglobulin

Identifiers

PMID38432957
PMCPMC11557205
OpenAlexW4392442990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.