Evidence map›Paper›PMID 38432868›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2023

A case of mitochondrial myopathy and chronic progressive external ophthalmoplegia.

Haokun Liu, Ming Gao, Qiying Sun, Si Chen, Yuebei Luo, Huan Yang, Qiuxiang Li, Jing Li, Guang Yang

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Haokun LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008. Liuhaokun@csu.edu.cn.
Ming GaoDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008.
Qiying SunDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008.
Si ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
Yuebei LuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
Huan YangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
Qiuxiang LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
Jing LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
Guang YangDepartment of General Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. yang_neurology@163.com.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

the Natural Science Foundation of Changsha kq2014279the Natural Science Foundation of Hunan Province 2021JJ41045 and 2021JJ31093
6 · The paper itself

Abstract

Mitochondrial myopathy is a group of multi-system diseases in which mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) defects lead to structural and functional dysfunction of mitochondria. The clinical manifestations of mitochondrial myopathy are complex and varied, and the testing for mtDNA and nDNA is not widely available, so misdiagnosis or missed diagnosis is common. Chronic progressive external ophthalmoplegia (CPEO) is a common type of mitochondrial myopathy, which is characterized by blepharoptosis. Here we report a 38-year-old female with mitochondrial myopathy presented with chronic numbness and weakness of the limbs, accompanied by blepharoptosis that was recently noticed. Laboratory and head magnetic resonance imaging (MRI) examinations showed no obvious abnormalities. Muscle and nerve biopsies showed characteristic ragged red fibers (RRFs) and large aggregates of denatured mitochondria. Testing for mtDNA and nDNA showed a known mutation c.2857C>T (p.R953C) and a novel variant c.2391G>C (p.M797I) in the polymerase gamma (

Indexed as

BlepharoptosisMitochondrial MyopathiesOphthalmoplegia, Chronic Progressive ExternalAdultDNA, MitochondrialFemaleHumansMitochondriaDNA, Mitochondrialblepharoptosishistopathologic examinationmitochondrial DNAmitochondrial myopathynuclear DNA

Identifiers

PMID38432868
PMCPMC10929950
OpenAlexW4394758548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.