Evidence map›Paper›PMID 38432523›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2024

Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.

James L Bernat, Kiran K Khush, Sam D Shemie, Matthew G Hartwig, Peter P Reese, Anne Dalle Ave, Brendan Parent, Alexandra K Glazier, Alexander M Capron, Matt Craig and 18 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 5 countries.

James L BernatDepartment of Neurology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire. Electronic address: bernat@dartmouth.edu.
Kiran K KhushDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.
Sam D ShemieDivision of Critical Care Medicine, Montreal Children's Hospital, McGill University, Montreal, PQ, Canada.
Matthew G HartwigDivision of Thoracic Surgery, Department of Surgery, Duke University Health System, Durham, North Carolina.
Peter P ReeseCenter for Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Anne Dalle AveKennedy Institute of Ethics, Georgetown University, Washington, District of Columbia.
Brendan ParentDivision of Medical Ethics and Department of Surgery, NYU Grossman School of Medicine, New York, New York.
Alexandra K GlazierBrown University, School of Public Health, Providence, Rhode Island; New England Donor Services, Waltham, Massachusetts.
Alexander M CapronGould School of Law and Keck School of Medicine, University of Southern California, Los Angeles, California.
Matt CraigLung Biology and Disease Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland.
Teneille GoftonDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Elisa J GordonDepartment of Surgery, Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee.
Andrew HealeyDepartment of Medicine McMaster University and William Osler Health System, Hamilton, Ontario, Canada.
Mary E HomanCommonSpirit Health, Chicago, Illinois.
Keren LadinResearch on Ethics, Aging, and Community Health (REACH Lab); Departments of Occupational Therapy and Community Health, Tufts University, Medford, Massachusetts.
Simon MesserDepartment of Transplant, Golden Jubilee National Hospital, Clydebank, Scotland UK.
Nick MurphyDepartments of Medicine and Philosophy, Western University, London, Ontario, Canada.
Thomas A NakagawaUniversity of Florida College of Medicine-Jacksonville, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Jacksonville, Florida.
William F ParkerDepartment of Medicine and Public Health Sciences, University of Chicago, Chicago, Illinois.
Rebecca D PentzWinship Cancer Institute, Emory University, Atlanta, Georgia.
David Rodríguez-AriasFiloLab-UGR, Philosophy I Department, Universidad de Granada, Granada, Spain.
Bryanna SchwartzDivision of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, Maryland; Department of Cardiology, Children's National Medical Center, Washington, District of Columbia.
Daniel P SulmasyThe Kennedy Institute of Ethics and the Departments of Medicine and Philosophy, Georgetown University, Washington, District of Columbia.
Robert D TruogDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital; Center for Bioethics, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
Anji E WallDepartment of Surgery, Baylor University Medical Center, Dallas, Texas.
Stephen P WallRonald O. Perelman Department of Emergency Medicine; NYU Grossman School of Medicine and Department of Population Health, NYU, New York, New York.
Paul R WolpeCenter for Ethics, Department of Medicine, Emory University, Atlanta, Georgia.
Kathleen N FentonAdvanced Technologies and Surgery Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, and Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Emory University · USGeorgetown University · USNew York University · USWestern University · CABaylor University Medical Center · USBoston Children's Hospital · USBrown University · USChicago Department of Public Health · USChildren's National · USDartmouth College · USDuke University Health System · USGolden Jubilee National Hospital · GBMontreal Children's Hospital · CANational Heart Lung and Blood Institute · USNational Institutes of Health · USStanford University · USTufts University · USUniversidad de Granada · ESUniversity of Florida · USUniversity of Pennsylvania · US

Funding

Mending a Broken Heart Allocation System with Machine LearningK08HL150291 · NHLBI · UNIVERSITY OF CHICAGO · PI PARKER, WILLIAM F · 2020 to 2024
$713k
Intramural NIH HHS Z99 HL999999NHLBI NIH HHS K08 HL150291
6 · The paper itself

Abstract

In a workshop sponsored by the U.S. National Heart, Lung, and Blood Institute, experts identified current knowledge gaps and research opportunities in the scientific, conceptual, and ethical understanding of organ donation after the circulatory determination of death and its technologies. To minimize organ injury from warm ischemia and produce better recipient outcomes, innovative techniques to perfuse and oxygenate organs postmortem in situ, such as thoracoabdominal normothermic regional perfusion, are being implemented in several medical centers in the US and elsewhere. These technologies have improved organ outcomes but have raised ethical and legal questions. Re-establishing donor circulation postmortem can be viewed as invalidating the condition of permanent cessation of circulation on which the earlier death determination was made and clamping arch vessels to exclude brain circulation can be viewed as inducing brain death. Alternatively, TA-NRP can be viewed as localized in-situ organ perfusion, not whole-body resuscitation, that does not invalidate death determination. Further scientific, conceptual, and ethical studies, such as those identified in this workshop, can inform and help resolve controversies raised by this practice.

Indexed as

DeathTissue and Organ ProcurementHeart TransplantationHumansLung TransplantationNational Heart, Lung, and Blood Institute (U.S.)Organ PreservationTissue DonorsUnited Statesdead donor rulenormothermic regional perfusionorgan donation after the circulatory determination of deathunified brain-based determination of deathUniform Determination of Death Act

Identifiers

PMID38432523
PMCPMC11132427
OpenAlexW4392346997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.