Evidence map›Paper›PMID 38432315›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2024

Transcriptional priming and chromatin regulation during stochastic cell fate specification.

Alison J Ordway, Rina N Helt, Robert J Johnston

Open access · hybridAbstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Stochastic processes in development and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alison J OrdwayDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Rina N HeltDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Robert J JohnstonDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0002-5775-6218
Johns Hopkins University · US

Funding

Mechanisms controlling stochastic gene expression during eye developmentR01EY025598 · NEI · JOHNS HOPKINS UNIVERSITY · PI Robert John Johnston · 2015 to 2026
$4.9M
Hedgehog Signaling Coordinates Stochastic and Stereotyped Patterns in the Drosophila EyeF32EY034378 · NEI · JOHNS HOPKINS UNIVERSITY · PI ORDWAY, ALISON J · 2022 to 2025
$219k
NEI NIH HHS F32 EY034378NEI NIH HHS R01 EY025598
6 · The paper itself

Abstract

Stochastic cell fate specification, in which a cell chooses between two or more fates with a set probability, diversifies cell subtypes in development. Although this is a vital process across species, a common mechanism for these cell fate decisions remains elusive. This review examines two well-characterized stochastic cell fate decisions to identify commonalities between their developmental programmes. In the fly eye, two subtypes of R7 photoreceptors are specified by the stochastic ON/OFF expression of a transcription factor,

Indexed as

ChromatinNeuronsAllelesAnimalsCell DifferentiationMiceProbabilityChromatincell fate specificationchromatinfly eyemouse olfactory systemstochastictranscription

Identifiers

PMID38432315
PMCPMC10909510
OpenAlexW4392342842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.