Evidence map›Paper›PMID 38432215›Full record

SynthesisIntervirology2024

Efficacy and Clinical Outcomes of mRNA COVID-19 Vaccine in Pregnancy: A Systematic Review and Meta-Analysis.

Antonio J Santimano, Raed M Al-Zoubi, Ahmad R Al-Qudimat, Mohamed B Al Darwish, Laxmi Kumari Ojha, Mohamed Amine Rejeb, Yasser Hamad, Malaz A Elrashid, Noorah M Ruxshan, Abdelfatteh El Omri and 6 more

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Intervirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

Antonio J SantimanoSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Raed M Al-ZoubiSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Ahmad R Al-QudimatSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Mohamed B Al DarwishSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Laxmi Kumari OjhaSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Mohamed Amine RejebSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Yasser HamadDepartment of Quality and Patients Safety, Rehabilitation Institute, Hamad Medical Corporation, Doha, Qatar.
Malaz A ElrashidSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Noorah M RuxshanSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Abdelfatteh El OmriSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Hiba BawadiDepartment of Nutrition, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar.
Maha A Al-AsmakhDepartment of Biomedical Sciences, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar.
Aksam YassinSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Omar M AboumarzoukSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Ahmad ZarourAcute Care Surgery Division, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Abdulla A Al-AnsariSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Hamad Medical Corporation · QAQatar University · QADresden International University · DEJordan University of Science and Technology · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe world has witnessed one of the largest pandemics, dubbed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of December 2020, the USA alone reported 98,948 cases of coronavirus disease 2019 (COVID-19) infection during pregnancy, with 109 related maternal deaths. Current evidence suggests that unvaccinated pregnant women infected with SARS-CoV-2 are at a higher risk of experiencing complications related to COVID-19 compared to nonpregnant women. This review aimed to provide healthcare workers and non-healthcare workers with a comprehensive overview of the available information regarding the efficacy of vaccines in pregnant women. SUMMARY: We performed a systematic review and meta-analysis following PRISMA guidelines. The search through the database for articles published between December 2019 and October 2021 was performed. A comprehensive search was performed in PubMed, Scopus, and EMBASE databases for research publications published between December 2019 and October 2021. We focused on original research, case reports, case series, and vaccination side effect by authoritative health institutions. Phrases used for the Medical Subject Heading [MeSH] search included ("COVID-19" [MeSH]) or ("Vaccine" [MeSH]) and ("mRNA" [MeSH]) and ("Pregnant" [MeSH]). Eleven studies were selected and included, with a total of 46,264 pregnancies that were vaccinated with mRNA-containing lipid nanoparticle vaccine from Pfizer/BioNTech and Moderna during pregnancy. There were no randomized trials, and all studies were observational (prospective, retrospective, and cross-sectional). The mean maternal age was 32.2 years, and 98.7% of pregnant women received the Pfizer COVID-19 vaccination. The local and systemic adverse effects of the vaccination in pregnant women were analyzed and reported. The local adverse effects of the vaccination (at least 1 dose) such as local pain, swelling, and redness were reported in 32%, 5%, and 1%, respectively. The systemic adverse effects such as fatigue, headaches, new onset or worsening of muscle pain, chills, fever, and joint pains were also reported in 25%, 19%, 18%, 12%, 11%, and 8%, respectively. The average birthweight was 3,452 g. Among these pregnancies, 0.03% were stillbirth and 3.68% preterm (<37 weeks) births. KEY MESSAGES: The systemic side effect profile after administering the COVID-19 mRNA vaccine to pregnant women was similar to that in nonpregnant women. Maternal and fetal morbidity and mortality were lowered with the administration of either one or both the doses of the mRNA COVID-19 vaccination.

Indexed as

COVID-19COVID-19 VaccinesPregnancy Complications, InfectiousSARS-CoV-2FemaleHumansmRNA VaccinesPregnancyVaccine EfficacyCOVID-19 VaccinesmRNA VaccinesComplicationsCOVID-19mRNAOutcomesPregnantVaccine

Identifiers

PMID38432215
PMCPMC11006275
OpenAlexW4394739935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.