Evidence map›Paper›PMID 38431842›Full record

ArticleCell reports2024

GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABA

Jyoti C Patel, Ang D Sherpa, Riccardo Melani, Paul Witkovsky, Madeline R Wiseman, Brian O'Neill, Chiye Aoki, Nicolas X Tritsch, Margaret E Rice

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  7. Article
  8. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  9. Review
  10. Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Review
  13. Dopamine-Glutamate and Dopamine-GABA Co-release.Advances in neurobiology · 2025
    Review
  14. Article
  15. Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jyoti C PatelDepartment of Neurosurgery, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: jyotiben.patel@nyulangone.org.
Ang D SherpaDepartment of Neurosurgery, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA; Center for Neural Science New York University, 4 Washington Place, New York, NY 10003, USA.
Riccardo MelaniNYU Neuroscience Institute, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Paul WitkovskyDepartment of Neurosurgery, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Madeline R WisemanDepartment of Neurosurgery, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Brian O'NeillDepartment of Neurosurgery, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Chiye AokiNYU Neuroscience Institute, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA; Center for Neural Science New York University, 4 Washington Place, New York, NY 10003, USA.
Nicolas X TritschNYU Neuroscience Institute, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Margaret E RiceDepartment of Neurosurgery, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA; NYU Neuroscience Institute, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: margaret.rice@nyu.edu.
New York University · US

Funding

Diet, Insulin, Dopamine, and RewardR01DA050165 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARR, KENNETH D, RICE, MARGARET E · 2020 to 2024
$3.0M
A novel framework for the functional dissection of motor systemsDP2NS105553 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2017 to 2017
$2.5M
Dopamine Release Regulation by Co-Released Glutamate and GABAR01DA038616 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICE, MARGARET E · 2015 to 2019
$2.0M
NIDA NIH HHS R01 DA038616NIDA NIH HHS R01 DA050165NINDS NIH HHS DP2 NS105553
6 · The paper itself

Abstract

Striatal dopamine axons co-release dopamine and gamma-aminobutyric acid (GABA), using GABA provided by uptake via GABA transporter-1 (GAT1). Functions of GABA co-release are poorly understood. We asked whether co-released GABA autoinhibits dopamine release via axonal GABA type A receptors (GABA

Indexed as

AutoreceptorsDopamineAnimalsAxonsCorpus Striatumgamma-Aminobutyric AcidHomeostasisMiceMice, KnockoutReceptors, GABA-AAutoreceptorsDopaminegamma-Aminobutyric AcidReceptors, GABA-AautoregulationCP: Neurosciencefast-scan cyclic voltammetryGABA receptorsimmuno-EMimmunohistochemistrymiceoptogenetic stimulationphasic-to-tonic dopamine signalingstriatal slicestransmitter co-release

Identifiers

PMID38431842
PMCPMC11089423
OpenAlexW4392346368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.