ArticleJournal of cancer research and clinical oncology2024
Influence of abdominal fat distribution and inflammatory status on post-operative prognosis in non-small cell lung cancer patients: a retrospective cohort study.
Article in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 6 citations in OpenAlex.
- Association between postoperative iliopsoas muscle cross-sectional area changes and prognosis in elderly patients with lung cancer.JTCVS open · 2026Article
- Artificial intelligence-driven body composition analysis and its association with survival in patients with colorectal liver metastases.Contemporary oncology (Poznan, Poland) · 2026Article
- Lumbar centroid level subcutaneous fat volume increased performance of prognostic predictive model in digestive system cancers: a real-world cohort study.Journal of gastrointestinal oncology · 2025Article
- Association between the age-adjusted visceral adiposity index (AVAI) and gynecologic malignancies: a cross-sectional study based on NHANES data.Translational cancer research · 2025Article
- Low Aggregate Index of Systemic Inflammation Values Correlate with Favorable Prognosis and High Abundance ofJournal of hepatocellular carcinoma · 2025Article
- Prognostic impact of CT-derived muscle-adipose index change in patients with inoperable esophageal squamous cell carcinoma undergoing chemoradiotherapy.Frontiers in oncology · 2025Article
- Article
- Role of Increasing Body Mass Index in Gut Barrier Dysfunction, Systemic Inflammation, and Metabolic Dysregulation in Obesity.Nutrients · 2024Article
- The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES.Eating and weight disorders : EWD · 2024Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the influence of visceral fat area (VFA), subcutaneous fat area (SFA), the systemic immune-inflammation index (SII) and total inflammation-based systemic index (AISI) on the postoperative prognosis of non-small cell lung cancers (NSCLC) patients.
methods266 NSCLC patients received surgery from two academic medical centers were included. To assess the effect of abdominal fat measured by computed tomography (CT) imaging and inflammatory indicators on patients' overall survival (OS) and progression-free survival (PFS), Kaplan-Meier survival analysis and Cox proportional hazards models were used.
resultsKaplan-Meier analysis showed the OS and PFS of patients in high-VFA group was better than low-VFA group (p < 0.05). AISI and SII were shown to be risk factors for OS and PFS (p < 0.05) after additional adjustment for BMI (Cox regression model II). After further adjustment for VFA (Cox regression model III), low-SFA group had longer OS (p < 0.05). Among the four subgroups based on VFA (high/low) and SFA (high/low) (p < 0.05), the high-VFA & low-SFA group had the longest median OS (108 months; 95% CI 74-117 months) and PFS (85 months; 95% CI 65-117 months), as well as the lowest SII and AISI (p < 0.05). Low-SFA was a protective factor for OS with different VFA stratification (p < 0.05).
conclusionVFA, SFA, SII and AISI may be employed as significant prognostic markers of postoperative survival in NSCLC patients. Moreover, excessive SFA levels may encourage systemic inflammation decreasing the protective impact of VFA, which may help to provide targeted nutritional support and interventions for postoperative NSCLC patients with poor prognosis.
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