Evidence map›Paper›PMID 38431711›Full record

ArticleScientific reports2024

A technique for repeated blood and cerebrospinal fluid sampling from individual rats over time without the need for repeated anesthesia.

Erin Santandrea, Farhang Aliakbari, Emily Truscott, Lynda McCaig, Neil S Donison, Danielle Graham, Michael J Strong, Kathryn Volkening

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Centrally administered thromboxane AScientific reports · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erin Santandrea *Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Farhang Aliakbari *Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Emily TruscottAnimal Care and Veterinary Services, University of Western Ontario, London, Canada.
Lynda McCaigMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Neil S DonisonMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Danielle GrahamMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Michael J StrongMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada. mstrong@uwo.ca.
Kathryn VolkeningMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.

Funding

CIHR SOP-160442
6 · The paper itself

Abstract

Ethical animal use follows the 3R's: Replacement, Reduction and Refinement. Here, we present the use of simultaneous jugular vein and cisterna magna catheterization via a port system in rats for repeated fluid sampling for 14 consecutive days without loss of catheter patency. This technique allows repeated intra-animal sampling without anesthesia and, if used with pooling samples from a cohort of animals, replaces the need for terminal collections for sufficient sample volumes.

Indexed as

AnesthesiaCisterna MagnaAnimalsCatheterizationCathetersCerebrospinal FluidHumansRatsSpecimen HandlingCerebrospinal fluidCisterna magnaExosomesJugular catheterizationRepeated samplingRodent

Identifiers

PMID38431711
PMCPMC10908789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.