Evidence map›Paper›PMID 38431661›Full record

ArticleRespiratory research2024

Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.

Wenhui Huang, Lianfang Wang, Zhipeng Huang, Zhichao Sun, Bojun Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  3. Molecular medicine reports · 2026
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  6. [SingleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Wenhui Huang *Department of Respiratory and Critical Care Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lianfang Wang *Department of Respiratory and Critical Care Medicine, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Guangxi, China.
Zhipeng HuangDongguan Hospital of Integrated Chinese and Western Medicine, Dongguan, China.
Zhichao SunThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Bojun ZhengDepartment of Critical Care Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. zhengbojun@gzucm.edu.cn.
Guangzhou University of Chinese Medicine · CNDongguan People’s Hospital · CNGuangzhou Medical University · CNSun Yat-sen University · CN

Funding

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 82104989Science and Technology Program of Guangzhou 202201020315The Guangdong Provincial Bureau of Traditional Chinese Medicine 20222065
6 · The paper itself

Abstract

Acute lung injury (ALI) is one of the life-threatening complications of sepsis, and macrophage polarization plays a crucial role in the sepsis-associated ALI. However, the regulatory mechanisms of macrophage polarization in ALI and in the development of inflammation are largely unknown. In this study, we demonstrated that macrophage polarization occurs in sepsis-associated ALI and is accompanied by mitochondrial dysfunction and inflammation, and a decrease of PRDX3 promotes the initiation of macrophage polarization and mitochondrial dysfunction. Mechanistically, PRDX3 overexpression promotes M1 macrophages to differentiate into M2 macrophages, and enhances mitochondrial functional recovery after injury by reducing the level of glycolysis and increasing TCA cycle activity. In conclusion, we identified PRDX3 as a critical hub integrating oxidative stress, inflammation, and metabolic reprogramming in macrophage polarization. The findings illustrate an adaptive mechanism underlying the link between macrophage polarization and sepsis-associated ALI.

Indexed as

Acute Lung InjuryMacrophagesPeroxiredoxin IIIAnimalsHumansInflammationLipopolysaccharidesMiceMitochondrial DiseasesSepsisLipopolysaccharidesPeroxiredoxin IIIPrdx3 protein, mouseMacrophage polarizationMetabolic reprogramMitochondrial functionPRDX3Sepsis-associated acute lung injury

Identifiers

PMID38431661
PMCPMC10909251
OpenAlexW4392350483

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.