Evidence map›Paper›PMID 38431618›Full record

ArticleBMC oral health2024

A newly developed kit for dental apical root resorption detection: efficacy and acceptability.

Jun Hong Steven Tan, Farinawati Yazid, Nurfathiha Abu Kasim, Shahrul Hisham Zainal Ariffin, Rohaya Megat Abdul Wahab

Open access · goldAbstract read
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jun Hong Steven TanDepartment of Family Oral Health, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia.
Farinawati YazidDepartment of Family Oral Health, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia.
Nurfathiha Abu KasimHalvec Laboratories Sdn. Bhd, G-E-4, Enterprise 4, Technology Park Malaysia, Bukit Jalil, Kuala Lumpur, 57000, GF, Malaysia.
Shahrul Hisham Zainal AriffinDepartment of Biosciences and Biotechnology, Faculty of Science, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.
Rohaya Megat Abdul WahabDepartment of Family Oral Health, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia. rohaya_megat@ukm.edu.my.
National University of Malaysia · MYGlobal Green Synergy (Malaysia) · MYUniversity Kebangsaan Malaysia Medical Centre · MY

Funding

Faculty of Dentistry, Universiti Kebangsaan Malaysia DD-2021-005
6 · The paper itself

Abstract

objectivesTo determine the efficacy of a newly developed kit in dentine sialophosphoprotein (DSPP) detection and compare it with enzyme-linked immunosorbent assay (ELISA). User acceptance was also determined. MATERIALS AND

methodsThis cross-sectional study consisted of 45 subjects who were divided into 3 groups based on the severity of root resorption using radiographs: normal (RO), mild (RM), and severe (RS). DSPP in GCF samples was analyzed using both methods. Questionnaires were distributed to 30 orthodontists to evaluate future user acceptance.

resultsThe sensitivity and specificity of the kit were 0.98 and 0.8 respectively. The DSPP concentrations measured using ELISA were the highest in the RS group (6.33 ± 0.85 ng/mL) followed by RM group (3.77 ± 0.36 ng/mL) and the RO group had the lowest concentration (2.23 ± 0.55 ng/mL). The new kit portrayed similar results as the ELISA, the optical density (OD) values were the highest in the RS group (0.62 ± 0.10) followed by RM group (0.33 ± 0.03) and the RO group (0.19 ± 0.06). The differences among all the groups were statistically significant (p < 0.05) for both methods. The Pearson correlation coefficient showed a statistically significant (p < 0.001) strong and positive correlation between DSPP concentrations and OD values.

conclusionsThe new kit was validated to detect the colour intensities of different severity of root resorptions. Most of the responses to the survey were positive towards the new kit for being a safer and simpler method to detect apical root resorption.

Indexed as

Extracellular Matrix ProteinsRoot ResorptionBiomarkersCross-Sectional StudiesGingival Crevicular FluidHumansPhosphoproteinsSialoglycoproteinsBiomarkersExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteinsBiomarkerDentine sialophosphoproteinGingival crevicular fluidOrthodonticRoot resorption

Identifiers

PMID38431618
PMCPMC10909286
OpenAlexW4392348931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.