ArticlePlant physiology2024
Natural polymorphisms in ZMET2 encoding a DNA methyltransferase modulate the number of husk layers in maize.
Article in Plant physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The CRISPR-dCas9 epigenetic toolbox: prospects for modulating gene expression in climate-resilient crops.Planta · 2026Review
- DNA methylation dynamics: patterns, regulation, and function.Current opinion in plant biology · 2025Review
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Genome-Wide Association Study and Candidate Gene Mining of Husk Number Trait in Maize.International journal of molecular sciences · 2025Article
- Natural variation in ZmNRT2.5 modulates husk leaf width and promotes seed protein content in maize.Plant biotechnology journal · 2025Article
- Heterozygous fasciated ear mutations improve yield traits in inbred and hybrid maize lines.Plant physiology · 2024Article
- More or less: The selection of indel in the 3'UTR of ZMET2 modules genome methylation and husk layer number in maize.Plant physiology · 2024Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
DNA methylation affects agronomic traits and the environmental adaptability of crops, but the natural polymorphisms in DNA methylation-related genes and their contributions to phenotypic variation in maize (Zea mays) remain elusive. Here, we show that a polymorphic 10-bp insertion/deletion variant in the 3'UTR of Zea methyltransferase2 (ZMET2) alters its transcript level and accounts for variation in the number of maize husk layers. ZMET2 encodes a chromomethylase and is required for maintaining genome-wide DNA methylation in the CHG sequence context. Disruption of ZMET2 increased the number of husk layers and resulted in thousands of differentially methylated regions, a proportion of which were also distinguishable in natural ZMET2 alleles. Population genetic analyses indicated that ZMET2 was a target of selection and might play a role in the spread of maize from tropical to temperate regions. Our results provide important insights into the natural variation of ZMET2 that confers both global and locus-specific effects on DNA methylation, which contribute to phenotypic diversity in maize.
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