Evidence map›Paper›PMID 38431093›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2024

Smart exosomes enhance PDAC targeted therapy.

Justin F Creeden, Jonathan Sevier, Jian-Ting Zhang, Yakov Lapitsky, F Charles Brunicardi, Ge Jin, John Nemunaitis, Jing-Yuan Liu, Andrea Kalinoski, Donald Rao and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  4. [Research progress on the mechanisms and optimization strategies of mesenchymal stem cell-derived exosomes in the treatment of liver diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
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  19. Extracellular Vesicle-Based Drug Delivery Systems in Cancer Therapy.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Justin F CreedenDepartment of Cell and Cancer Biology, University of Toledo, Toledo, OH, USA.
Jonathan SevierDepartment of Cell and Cancer Biology, University of Toledo, Toledo, OH, USA.
Jian-Ting ZhangDepartment of Cell and Cancer Biology, University of Toledo, Toledo, OH, USA.
Yakov LapitskyDepartment of Chemical Engineering, University of Toledo, Toledo, OH, USA.
F Charles BrunicardiDepartment of Surgery, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Ge JinDepartment of Medicine, Case Western Reserve University, Cleveland, OH, USA.
John NemunaitisGradalis Inc., Dallas, TX, USA.
Jing-Yuan LiuDepartment of Medicine, University of Toledo, Toledo, OH, USA.
Andrea KalinoskiDepartment of Surgery, University of Toledo, Toledo, OH, USA.
Donald RaoGradalis Inc., Dallas, TX, USA.
Shi-He LiuDepartment of Cell and Cancer Biology, University of Toledo, Toledo, OH, USA. Electronic address: shi-he.liu@utoledo.edu.
University of Toledo · USGradalis (United States) · USCase Western Reserve University · USSUNY Downstate Health Sciences University · US

Funding

Engineering Exosome for Pancreatic Cancer Targeting TherapiesR01CA276732 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI Shi-He Liu · 2023 to 2026
$2.0M
NCI NIH HHS R01 CA276732
6 · The paper itself

Abstract

Exosomes continue to attract interest as a promising nanocarrier drug delivery technology. They are naturally derived nanoscale extracellular vesicles with innate properties well suited to shuttle proteins, lipids, and nucleic acids between cells. Nonetheless, their clinical utility is currently limited by several major challenges, such as their inability to target tumor cells and a high proportion of clearance by the mononuclear phagocyte system (MPS) of the liver and spleen. To overcome these limitations, we developed "Smart Exosomes" that co-display RGD and CD47

Indexed as

Carcinoma, Pancreatic DuctalExosomesPancreatic NeoplasmsCD47 AntigenCell Line, TumorHumansCD47 AntigenBioengineeringCD47CD9Drug deliveryExosomesGemcitabinePaclitaxelPancreatic cancerRGD

Identifiers

PMID38431093
PMCPMC12312550
OpenAlexW4392572780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.