Evidence map›Paper›PMID 38430790›Full record

ArticleCell calcium2024

MLKL overexpression leads to Ca

Sathyaseelan S Deepa, Nidheesh Thadathil, Jorge Corral, Sabira Mohammed, Sophia Pham, Hadyn Rose, Michael T Kinter, Arlan Richardson, Carlos Manlio Díaz-García

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sathyaseelan S DeepaDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: deepa-sathyaseelan@ouhsc.edu.
Nidheesh ThadathilDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA.
Jorge CorralDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA.
Sabira MohammedDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Sophia PhamDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA.
Hadyn RoseDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA.
Michael T KinterAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Arlan RichardsonDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA.
Carlos Manlio Díaz-GarcíaDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, OK, USA. Electronic address: carlosmanlio-diazgarcia@ouhsc.edu.
University of Oklahoma Health Sciences Center · USOklahoma City VA Medical Center · USOklahoma Medical Research Foundation · US

Funding

Visualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI William Edmund Sonntag · 2019 to 2026
$17.8M
Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew John Hart · 2015 to 2026
$13.9M
The Role of Necroptosis in AgingR01AG059718 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Deepa Sathyaseelan · 2019 to 2026
$3.0M
Role of necroptosis in inflammation and NAFLD to HCC progressionR03CA262044 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SATHYASEELAN, DEEPA · 2022 to 2023
$145k
Effect of Necroptosis in Neurons on Neuroinflammation, Neuronal Function, and CognitionI01BX004538 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI FREEMAN, WILLARD M, RICHARDSON, ARLAN G. · 2019 to 2024
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BLRD VA I01 BX004538BLRD VA IK6 BX005238NCI NIH HHS R03 CA262044NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG059718NIGMS NIH HHS P20 GM125528
6 · The paper itself

Abstract

The necroptotic effector molecule MLKL accumulates in neurons over the lifespan of mice, and its downregulation has the potential to improve cognition through neuroinflammation, and changes in the abundance of synaptic proteins and enzymes in the central nervous system. Notwithstanding, direct evidence of cell-autonomous effects of MLKL expression on neuronal physiology and metabolism are lacking. Here, we tested whether the overexpression of MLKL in the absence of cell death in the neuronal cell line Neuro-2a recapitulates some of the hallmarks of aging at the cellular level. Using genetically-encoded fluorescent biosensors, we monitored the cytosolic and mitochondrial Ca

Indexed as

LactatesNeuronsAnimalsCell DeathCell LineGlucoseMiceProtein KinasesGlucoseLactatesMLKL protein, mouseProtein KinasesAgingCalciumLactateMetabolismMitochondriaMLKLNecroptosisNeuron

Identifiers

PMID38430790
PMCPMC10990772
OpenAlexW4391559804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.