SynthesisUnited European gastroenterology journal2024
Global trends in incidence and prevalence of achalasia, 1925-2021: A systematic review and meta-analysis.
Synthesis in United European gastroenterology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Long-term outcomes of peroral endoscopic myotomy for achalasia: a systematic review and meta-analysis with median follow-up ≥ 5 years.Surgical endoscopy · 2026Pooled it
- Global trends in incidence and prevalence of achalasia, 1925-2021: A systematic review and meta-analysis.United European gastroenterology journal · 2024Pooled it
- Achalasia in Geriatric Patients: A Comprehensive Overview.Digestive diseases and sciences · 2026Review
- Modern treatment for achalasia: endoscopic and surgical therapies.The British journal of surgery · 2026Review
- Article
- Association between preoperative pan-esophageal pressurization and peristalsis recovery after per-oral endoscopic myotomy in achalasia.Gastroenterology report · 2026Article
- Achalasia: Physician Practices and Knowledge in Türkiye.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Peroral endoscopic myotomy provides effective and sustained relief for achalasia in Allgrove syndrome: a long-term comparative cohort study.Frontiers in medicine · 2026Article
- Public-facing health information on achalasia generated by large language models: a multidimensional comparative study.Frontiers in public health · 2026Article
- Saudi Gastroenterology Association (SGA) clinical care pathway and standards of care for peroral endoscopic myotomy (POEM) in achalasia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- What worsens swallowing in esophageal achalasia? Insights from patient-reported outcomes.Frontiers in nutrition · 2026Article
- Article
- A Decade of Change: National Trends in Management and Outcomes of Achalasia Hospitalizations in the United States.Neurogastroenterology and motility · 2025Article
- Robotic Heller Myotomy for Achalasia: A Narrative Review of the State-of-the-Art Technique and Its Future Directions.Cureus · 2025Review
- A rare cause of acute upper airway obstruction: a case report.International journal of emergency medicine · 2025Article
- Epidemiology and practice patterns of achalasia in Taiwan: A nationwide population-based cohort study.Journal of the Chinese Medical Association : JCMA · 2025Article
- Focus on Achalasia in the Omics Era.International journal of molecular sciences · 2024Review
- Atypical Appearance on Radioiodine Scintigraphy Due to Achalasia Cardia - A Potential Diagnostic Pitfall.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundAchalasia poses a significant socioeconomic burden, yet global trends remain undocumented. This study aims to describe the worldwide trends in the incidence and prevalence of achalasia from 1925 to 2021 and explore their correlation with various factors through a comprehensive systematic review.
methodsWe searched the PubMed/MEDLINE, Embase, and Cochrane databases from inception to 30 June 2023, to identify studies reporting the incidence or prevalence of achalasia in the general population. This study utilized pooled estimates with 95% confidence intervals (CI) to estimate the incidence and prevalence of achalasia, and conducted various subgroup analyses.
resultsA total of 26 eligible studies covering approximately 269 million participants and 20,873 patients from 14 countries across five continents were included. Global pooled incidence and prevalence of achalasia were estimated to be 0.78 cases per 100,000 person-years (95% CI, 0.64-0.93; number of studies, 26; sample population, 269,315,171) and 10.82 cases per 100,000 person-years (95% CI, 8.15-13.48; number of studies, 14; sample population, 192,176,076), respectively. The incidence of achalasia was higher in Oceania (than Asia and Africa) and in adults (than children) after the introduction of the Chicago classification. Prevalence followed a similar pattern. The pooled incidence of achalasia showed an overall upward trend from 1925 to 2021 (1925-1999; 0.40 [0.32-0.49] vs. 2018-2021; 1.64 [1.33-1.95] cases per 100,000 person-years).
conclusionsThe incidence and prevalence of achalasia have notably increased, particularly with advancements in diagnosis, and show significant variation worldwide, despite the large heterogeneity within the sample population. Further studies are necessary to accurately assess the global incidence and prevalence of achalasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.