Trial reportEuropean heart journal2024
Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial.
Trial report in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Determinants and Implementation of Hybrid Cardiac Rehabilitation in Adolescents and Young Adults With Congenital Heart Disease: Insight From the QUALIREHAB Study.Journal of the American Heart Association · 2026Trial
- Home-based neuro-cardiac rehabilitation in congenital heart disease: the QUALINEURO-REHAB trial study protocol.BMJ open · 2026Article
- Perceptions of Patients and Health Professionals Regarding the Experience of Patients With a Hybrid Cardiac Rehabilitation Program.Research in nursing & health · 2026Article
- Elamipretide in pediatric Barth syndrome: from heart failure to school return.Orphanet journal of rare diseases · 2026Article
- Long-term health-related quality of life in pediatric ECMO survivors: a prospective controlled study.Pediatric research · 2026Article
- The FOOTLOOSE App: Evaluation of a Gamified App-Based Exercise Intervention for Children and Adolescents with Congenital Heart Disease-A Mixed-Methods Feasibility Study.Journal of cardiovascular development and disease · 2026Article
- Shared decision-making for preventive sports cardiology in youth with heart disease: a pilot study.Pediatric research · 2026Article
- Indian Expert Consensus on Hybrid Cardiac Rehabilitation in the Management of Cardiovascular Disease.Cureus · 2026Review
- Feasibility of an Individualized Exercise Training Program for Children with Hypertrophic Cardiomyopathy.Pediatric cardiology · 2026Article
- Neurocognitive and Psychological Interventions for Adults With Congenital Heart Disease: A Consensus Statement From the Adult Congenital Heart Disease/Neuro 2024 Conference.Journal of the American Heart Association · 2026Article
- Daily issues in the life of adults with congenital heart disease: new insights from EURO-ACHD Congress 2025.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Home-Based Cardiac Rehabilitation in Cardiovascular Diseases: A Narrative Review of Progress, Challenges, and Future Directions.Journal of multidisciplinary healthcare · 2026Review
- Baseline indices of cardiorespiratory fitness for predicting acute mountain sickness: an interpretable four-task ensemble model.Frontiers in public health · 2026Article
- Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission: a retrospective cohort study, 2020-2022.BMC pediatrics · 2025Article
- Cardiopulmonary Exercise Testing in Congenital Heart Disease: A Never-Ending Story from Paediatrics to Adult Life.Children (Basel, Switzerland) · 2025Review
- Interactive Telehealth Solutions for Patients With Congenital Heart Disease: A Systematic Review.CJC pediatric and congenital heart disease · 2025Review
- Hypoplastic left heart syndrome (HLHS) becomes of age: Assessing the young adult with HLHS including the neoaorta/aortic arch.International journal of cardiology. Congenital heart disease · 2025Review
- Cardiac rehabilitation in ACHD: Further investment is now due.International journal of cardiology. Congenital heart disease · 2025Article
- Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease.JAMA network open · 2025Article
- Physiological responses of children with surgically corrected congenital heart disease during high-altitude trekking: an exploratory observational study.Frontiers in pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 16 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
aimsCardiopulmonary fitness in congenital heart disease (CHD) decreases faster than in the general population resulting in impaired health-related quality of life (HRQoL). As the standard of care seems insufficient to encourage and maintain fitness, an early hybrid cardiac rehabilitation programme could improve HRQoL in CHD.
methodsThe QUALIREHAB multicentre, randomized, controlled trial evaluated and implemented a 12-week centre- and home-based hybrid cardiac rehabilitation programme, including multidisciplinary care and physical activity sessions. Adolescent and young adult CHD patients with impaired cardiopulmonary fitness were randomly assigned to either the intervention (i.e. cardiac rehabilitation) or the standard of care. The primary outcome was the change in HRQoL from baseline to 12-month follow-up in an intention-to-treat analysis. The secondary outcomes were the change in cardiovascular parameters, cardiopulmonary fitness, and mental health.
resultsThe expected number of 142 patients was enroled in the study (mean age 17.4 ± 3.4 years, 52% female). Patients assigned to the intervention had a significant positive change in HRQoL total score [mean difference 3.8; 95% confidence interval (CI) 0.2; 7.3; P = .038; effect size 0.34], body mass index [mean difference -0.7 kg/m2 (95% CI -1.3; -0.1); P = .022; effect size 0.41], level of physical activity [mean difference 2.5 (95% CI 0.1; 5); P = .044; effect size 0.39], and disease knowledge [mean difference 2.7 (95% CI 0.8; 4.6); P = .007; effect size 0.51]. The per-protocol analysis confirmed these results with a higher magnitude of differences. Acceptability, safety, and short-time effect of the intervention were good to excellent.
conclusionsThis early hybrid cardiac rehabilitation programme improved HRQoL, body mass index, physical activity, and disease knowledge, in youth with CHD, opening up the possibility for the QUALIREHAB programme to be rolled out to the adult population of CHD and non-congenital cardiac disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.