Evidence map›Paper›PMID 38430352›Full record

ArticleMolecular neurobiology2024

Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling.

Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra Dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Julia Eisenhardt de MelloPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0009-0002-1461-7063
Fernanda Cardoso TeixeiraPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, CEP 90050-170, Brazil.ORCID http://orcid.org/0000-0002-9195-981X
Alessandra Dos SantosPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.
Karina LuduvicoPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0001-7002-5391
Mayara Sandrielly Soares de AguiarPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0002-2181-3591
William Borges DominguesPrograma de Pós-Graduação em Biotecnologia, Universidade Federal de Pelotas, Campus Universitário Capão do Leão, S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0002-4351-2271
Vinicius Farias CamposPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0003-2119-293X
Rejane Giacomelli TavaresPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Universidade Federal de Pelotas, Campus Universitário Capão Do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0002-9806-1893
Augusto SchneiderPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0002-3410-2860
Francieli Moro StefanelloPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil.ORCID http://orcid.org/0000-0001-5945-3723
Roselia Maria SpanevelloPrograma de Pós‑Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Campus Universitário Capão do Leão S/N, Pelotas, RS, CEP 96010‑900, Brazil. rspanevello@gmail.com.ORCID http://orcid.org/0000-0002-5117-2000
Universidade Federal de Pelotas · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products offer promising potential for the development of new therapies for Alzheimer's disease (AD). Blackberry fruits are rich in phytochemical compounds capable of modulating pathways involved in neuroprotection. Additionally, drug repurposing and repositioning could also accelerate the development of news treatments for AD. In light of the reduced brain glucose metabolism in AD, an alternative approach has been the use of the drug metformin. Thus, the aim of this study was to evaluate the effect of treatment with blackberry extract in a model of AD induced by streptozotocin (STZ) and compare it with metformin treatment. Male rats were divided into groups: I - Control; II - STZ; III - STZ + blackberry extract (100 mg/kg); IV - STZ + blackberry extract (200 mg/kg) and V - STZ + metformin (150 mg/kg). The animals received intracerebroventricular injection of STZ or buffer. Seven days after the surgical procedure, the animals were treated orally with blackberry extract or metformin for 21 days. Blackberry extract and metformin prevented the memory impairment induced by STZ. In animals of group II, an increase in acetylcholinesterase activity, phosphorylated tau protein, IL-6, oxidative damage, and gene expression of GSK-3β and Nrf2 was observed in the hippocampus. STZ induced a decrease in IL-10 levels and down-regulated the gene expression of Akt1, IRS-1 and FOXO3a. Blackberry extract and metformin prevented the alterations in acetylcholinesterase activity, IL-6, GSK3β, Nrf2, and oxidative damage. In conclusion, blackberry extract exhibits multi-target actions in a model of AD, suggesting new therapeutic potentials for this neurodegenerative disease.

Indexed as

Alzheimer DiseaseDisease Models, AnimalInflammationInsulinMemoryMetforminOxidation-ReductionPlant ExtractsRats, WistarRubusSignal Transductiontau ProteinsAnimalsMaleOxidative StressPhosphorylationInsulinMetforminPlant ExtractsStreptozocintau ProteinsBlackberryHippocampusMemoryMetforminRatStreptozotocin

Identifiers

PMID38430352
OpenAlexW4392348115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.