Evidence map›Paper›PMID 38430327›Full record

ArticleInfectious diseases and therapy2024

4CMenB Vaccination to Prevent Meningococcal B Disease in Vietnam: Expert Review and Opinion.

Phung Nguyen The Nguyen, Pham Quang Thai, Tran Minh Dien, Do Thien Hai, Vo Thi Trang Dai, Nguyen Huy Luan, Gaurav Mathur, Selim Badur, Doan Minh Truyen, Nguyen Hoan Le Minh

Open access · goldAbstract read
In one paragraph

Article in Infectious diseases and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Genetic and Antigenic Diversity ofPathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Phung Nguyen The NguyenPediatrics Department, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID http://orcid.org/0000-0003-2444-1786
Pham Quang ThaiCommunicable Diseases Control and Prevention Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.ORCID http://orcid.org/0000-0002-3796-6162
Tran Minh DienNational Pediatric Hospital, Hanoi, Vietnam.
Do Thien HaiCenter for Tropical Diseases, National Pediatric Hospital, Hanoi, Vietnam.
Vo Thi Trang DaiRespiratory Microbiology Bacteria Laboratory, Department of Immunology and Microbiology, the Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Nguyen Huy LuanImmunization Unit of University of Medicine and Pharmacy Hospital, Pediatrics Department, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID http://orcid.org/0009-0000-0975-8369
Gaurav MathurGSK, Ho Chi Minh City, Vietnam.
Selim BadurGSK, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1316-6259
Doan Minh TruyenGSK, Ho Chi Minh City, Vietnam.
Nguyen Hoan Le MinhGSK, Ho Chi Minh City, Vietnam. minh.l.nguyen-hoan@gsk.com.
University of Medicine and Pharmacy at Ho Chi Minh City · VNHospital for Tropical Diseases · VNInstitut Pasteur in Ho Chi Minh City · VNNational Institute Of Hygiene And Epidemiology · VNTrường ĐH Nguyễn Tất Thành · VNVietnam National Children's Hospital · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An advisory board meeting was held with experts in Vietnam (Hanoi, August 2022), to review the evidence on invasive meningococcal disease (IMD) epidemiology, clinical management, and meningococcal vaccines to reach a consensus on recommendations for meningococcal vaccination in Vietnam. IMD is a severe disease, with the highest burden in infants and children. IMD presents as meningitis and/or meningococcemia and can progress extremely rapidly. Almost 90% of deaths in children occur within the first 24 h, and disabling sequelae (e.g., limb amputations and neurological damage) occur in up to 20% of survivors. IMD patients are often hospitalized late, due to mild and nonspecific early symptoms and misdiagnosis. Difficulties related to diagnosis and antibiotic misuse mean that the number of reported IMD cases in Vietnam is likely to be underestimated. Serogroup B IMD is predominant in many regions of the world, including Vietnam, where 82% of IMD cases were due to serogroup B (surveillance data from 2012 to 2021). Four component meningococcal B vaccine (4CMenB) is used in many countries (and is part of the pediatric National Immunization Program in 13 countries), with infant vaccination starting from two months of age, and a 2 + 1 dosing schedule. Experts recommend 4CMenB vaccination as soon as possible in Vietnam, starting from two months of age, with a 2 + 1 dosing schedule, and at least completing one dose before 6 months of age.

Indexed as

4CMenBInfantInvasive meningococcal diseaseVaccinationVietnam

Identifiers

PMID38430327
PMCPMC10965853
OpenAlexW4392349988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.