ArticleJACC. Clinical electrophysiology2024
Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults.
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Article in JACC. Clinical electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
23.5field-weighted citation impact, top 1% of its field
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9 citing papers in PubMed, 25 citations in OpenAlex.
- Selective activation of tetrodotoxin-sensitive sodium channels by AaH-II drives arrhythmogenic late Na+ current in the heart.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Monte Carlo modeling of the formation and organization of ion channel clustering.PLoS computational biology · 2026Article
- Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels.Nature communications · 2026Article
- Selectivity Filter Mutation in NaJACC. Clinical electrophysiology · 2026Article
- Loss of cyclin-dependent kinase-like 5 results in susceptibility to audiogenic seizures in mice.Epilepsia open · 2026Article
- Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics.Biomedicines · 2025Review
- Article
- Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions.Cardiovascular research · 2025Review
- Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling.BMC biology · 2024Article
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Authors and funding
17 authors at 2 institutions in 2 countries.
D Ryan KingThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Mustafa DemirtasThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Mikhail TarasovThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Heather L StruckmanThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Xiaolei MengThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Drew NassalThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Nicolae MoiseThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Alec MillerThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Dennison MinThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Andrew M SoltiszThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Midhun N K AnneThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Patrícia A Alves DiasThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Akademika Heyrovského Hradec Králové, Czech Republic.
Jacy L WagnonThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Seth H WeinbergThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Thomas J HundThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; Department of Internal Medicine, Division of Cardiovascular Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Rengasayee VeeraraghavanThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Przemysław B RadwańskiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA. Electronic address: radwanski.2@osu.edu.
The Ohio State University Wexner Medical Center · USCharles University · CZ
Funding
Regulation and dysregulation of sodium channels by by calmodulinR01HL155378 · NHLBI · OHIO STATE UNIVERSITY · PI RADWANSKI, PRZEMYSLAW · 2021 to 2025
$2.5MTargeting Vascular Leak and Intercalated Disk Nanodomains to Prevent Atrial FibrillationR01HL148736 · NHLBI · OHIO STATE UNIVERSITY · PI VEERARAGHAVAN, RENGASAYEE · 2020 to 2024
$2.2MDefining Novel Mechanisms of Sudden Death in Dravet Syndrome: Dysregulation of Sodium Channels in the HeartR01NS121234 · NINDS · OHIO STATE UNIVERSITY · PI Przemyslaw Radwanski · 2022 to 2026
$2.1MRole of TREK-1 in modulating cardiac excitability and arrhythmiaR01HL156652 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2021 to 2024
$1.7MPostdoctoral Training in Cardiometabolic ScienceT32HL149637 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A, SMITH, SAKIMA AHMAD · 2020 to 2024
$1.5MRegulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophyR00HL157684 · NHLBI · OHIO STATE UNIVERSITY · PI Drew Nassal · 2024 to 2026
$747kRegulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophyK99HL157684 · NHLBI · OHIO STATE UNIVERSITY · PI NASSAL, DREW · 2022 to 2023
$224kNHLBI NIH HHS K99 HL157684NHLBI NIH HHS R00 HL157684NHLBI NIH HHS R01 HL148736NHLBI NIH HHS R01 HL155378NHLBI NIH HHS R01 HL156652NHLBI NIH HHS T32 HL149637NINDS NIH HHS L40 NS129034NINDS NIH HHS R01 NS121234
Abstract
backgroundSudden unexpected death in epilepsy (SUDEP) is a fatal complication experienced by otherwise healthy epilepsy patients. Dravet syndrome (DS) is an inherited epileptic disorder resulting from loss of function of the voltage-gated sodium channel, Na
objectivesIn this study, the authors sought to provide evidence implicating remodeling of Na
methodsThe authors undertook scanning ion conductance microscopy (SICM)-guided patch clamp, super-resolution microscopy, confocal Ca
resultsDS promotes I
conclusionsThese data demonstrate that Na
Indexed as
Epilepsies, MyoclonicNAV1.6 Voltage-Gated Sodium ChannelAnimalsArrhythmias, CardiacCalciumFemaleHumansMaleMiceMice, KnockoutMyocytes, CardiacSodium-Calcium ExchangerSudden Unexpected Death in EpilepsyCalciumNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseSodium-Calcium ExchangerDravet syndromeNa(V)1.6sodium channelssudden cardiac deathsudden unexpected death in epilepsy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.