Evidence map›Paper›PMID 38429970›Full record

ArticleMolecular oncology2024

Dual role of GRHL3 in bladder carcinogenesis depending on histological subtypes.

Franziska C Lammert, Julia Pannhausen, Erik Noetzel, Florian Friedland, Julia Wirtz, Yannick Herfs, Sophie Leypold, Lin Gan, Ralf Weiskirchen, Tician Schnitzler and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Franziska C LammertInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.
Julia PannhausenInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.
Erik NoetzelInstitute of Biological Information Processing 2 (IBI-2), Mechanobiology, Forschungszentrum Jülich GmbH, Germany.
Florian FriedlandInstitute of Biological Information Processing 2 (IBI-2), Mechanobiology, Forschungszentrum Jülich GmbH, Germany.
Julia WirtzInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.
Yannick HerfsInstitute of Biological Information Processing 2 (IBI-2), Mechanobiology, Forschungszentrum Jülich GmbH, Germany.
Sophie LeypoldInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.
Lin GanIZKF Aachen, Medical Faculty of the RWTH Aachen University, Germany.
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital, RWTH Aachen University, Germany.
Tician SchnitzlerInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.
Ruth KnüchelInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.
Jochen MaurerDepartment of Obstetrics and Gynecology, University Hospital Aachen, Germany.
Danny D JonigkInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.ORCID 0000-0002-5251-2281
Michael RoseInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.ORCID 0000-0002-4340-1117
Nadine T GaisaInstitute of Pathology, University Hospital, RWTH Aachen University, Germany.ORCID 0000-0002-4762-3964
Integrated Oncology (United States) · USRWTH Aachen University · DEForschungszentrum Jülich · DEUniversität Ulm · DEUniversitätsklinikum Aachen · DE

Funding

START Program of the Medical Faculty of the RWTH Aachen University 62/22
6 · The paper itself

Abstract

The effect of grainyhead-like transcription factor 3 (GRHL3) on cancer development depends on the cancer subtypes as shown in tumor entities such as colorectal or oral squamous cell carcinomas. Here, we analyzed the subtype-specific role of GRHL3 in bladder carcinogenesis, comparing common urothelial carcinoma (UC) with squamous bladder cancer (sq-BLCA). We examined GRHL3 mRNA and protein expression in cohorts of patient samples, its prognostic role and its functional impact on tumorigeneses in different molecular and histopathological subtypes of bladder cancer. We showed for GRHL3 a reverse expression in squamous and urothelial bladder cancer subtypes. Stably GRHL3-overexpressing EJ28, J82, and SCaBER in vitro models revealed a tumor-suppressive function in squamous and an oncogenic role in the urothelial cancer cells affecting cell and colony growth, and migratory and invasive capacities. Transcriptomic profiling demonstrated highly subtype-specific GRHL3-regulated expression networks coined by the enrichment of genes involved in integrin-mediated pathways. In SCaBER, loss of ras homolog family member A (RHOA) GTPase activity was demonstrated to be associated with co-regulation of eukaryotic translation initiation factor 4E family member 3 (EIF4E3), a potential tumor suppressor gene. Thus, our data provide for the first time a detailed insight into the role of the transcription factor GRHL3 in different histopathological subtypes of bladder cancer.

Indexed as

CarcinogenesisDNA-Binding ProteinsGene Expression Regulation, NeoplasticTranscription FactorsUrinary Bladder NeoplasmsAgedCarcinoma, Squamous CellCell Line, TumorCell MovementCell ProliferationEukaryotic Initiation Factor-4EFemaleHumansMalePrognosisrhoA GTP-Binding ProteinDNA-Binding ProteinsEukaryotic Initiation Factor-4EGRHL3 protein, humanrhoA GTP-Binding ProteinTranscription Factorsbladder cancerGRHL3oncogeneRHO GTPasesquamous cell carcinomatumor suppressor gene

Identifiers

PMID38429970
PMCPMC11164254
OpenAlexW4392347420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.